Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22624012 | 0.85 | NPC1 (0.62) | NPC1RAB9AHTR7PTPN1LMNA | |
| SCHEMBL11115633 | 0.81 | NPC1 (0.52) | NPC1RAB9AHTR7PTPN1LMNA | |
| SCHEMBL2074096 | 0.79 | NPC1 (0.64) | NPC1RAB9AHTR7PTPN1LMNA | |
| SCHEMBL28408325 | 0.79 | NPC1 (0.50) | NPC1RAB9AHTR7PTPN1LMNA | |
| SCHEMBL26045299 | 0.79 | NPC1 (0.58) | NPC1RAB9AHTR7PTPN1LMNA | |
| SCHEMBL9977572 | 0.78 | NPC1 (0.53) | NPC1RAB9AHTR7PTPN1LMNA | |
| SCHEMBL26584242 | 0.78 | NPC1 (0.82) | NPC1RAB9AHTR7PTPN1PLOD2 | |
| SCHEMBL10771341 | 0.77 | ALDH1A1 (0.57) | NPC1RAB9AHTTKMT2ASMN1; SMN2 | |
| SCHEMBL2490498 | 0.75 | HTR7 (0.78) | NPC1RAB9AHTR7PTPN1PLOD2 | |
| SCHEMBL13770482 | 0.75 | NPC1 (0.69) | NPC1RAB9AHTR7PTPN1PLOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3889138-A1 | HISTONE ACETYLASE P300 INHIBITOR AND USE THEREOF | Hinova Pharmaceuticals Inc. (CN) | 2021-10-06 | — | — | EP | disclosed |