Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.31 |
| ▸ | ADK | P55263 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25949326 | 0.92 | GPR119 (0.33) | GPR119JAK3JAK1JAK2METTL3 | |
| SCHEMBL22002163 | 0.92 | PDPK1 (0.37) | GPR119JAK3JAK1METTL3PRMT5 | |
| SCHEMBL25949266 | 0.92 | PDPK1 (0.37) | GPR119JAK3JAK1METTL3PRMT5 | |
| SCHEMBL22002066 | 0.83 | PDPK1 (0.36) | GPR119JAK3PRMT5WDR77ADK | |
| SCHEMBL23892341 | 0.83 | PDPK1 (0.36) | GPR119JAK3PRMT5WDR77ADK | |
| SCHEMBL25949197 | 0.79 | JAK3 (0.33) | GPR119JAK3METTL3 | |
| SCHEMBL18572228 | 0.77 | PDPK1 (0.40) | GPR119JAK3 | |
| SCHEMBL18571923 | 0.77 | PDPK1 (0.40) | GPR119JAK3 | |
| SCHEMBL25047421 | 0.76 | JAK1 (0.38) | GPR119JAK3JAK1JAK2PRMT5 | |
| SCHEMBL23892497 | 0.75 | PRMT5 (0.32) | METTL3PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3341368-B1 | NOVEL 6-6 BICYCLIC AROMATIC RING SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-06 | — | — | EP | disclosed |