Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | PPARA | Q07869 | 1/20 | 0.54 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.53 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SPHK2 | Q9NRA0 | 5/20 | 0.47 |
| ▸ | SPHK1 | Q9NYA1 | 5/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31346653 | 0.92 | RAB9A (0.56) | L3MBTL1NPC1RAB9AMAPK1TDP1 | |
| SCHEMBL31346686 | 0.86 | S1PR1 (0.57) | L3MBTL1NPC1RAB9AMAPK1TDP1 | |
| SCHEMBL21974272 | 0.82 | RAB9A (0.69) | L3MBTL1NPC1RAB9AMAPK1TDP1 | |
| SCHEMBL13167065 | 0.81 | L3MBTL1 (0.67) | L3MBTL1NPC1RAB9AMAPK1TDP1 | |
| SCHEMBL59281 | 0.81 | ALDH1A1 (0.56) | L3MBTL1NPC1RAB9AMAPK1TDP1 | |
| SCHEMBL26887342 | 0.80 | SPHK1 (0.57) | L3MBTL1NPC1RAB9AMAPK1TDP1 | |
| SCHEMBL13167064 | 0.80 | ALDH1A1 (0.52) | L3MBTL1NPC1RAB9AMAPK1TDP1 | |
| SCHEMBL16572030 | 0.80 | PPARA (0.52) | L3MBTL1NPC1RAB9AMAPK1TDP1 | |
| SCHEMBL2094536 | 0.80 | PPARA (0.55) | L3MBTL1NPC1RAB9AMAPK1TDP1 | |
| SCHEMBL6334541 | 0.79 | KMT2A (0.55) | L3MBTL1NPC1RAB9AMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4101846-A1 | 1,2,4-OXADIAZOLE BENZOIC ACID COMPOUNDS AND THEIR USE FOR NONSENSE SUPPRESSION AND THE TREATMENT OF DISEASE | PTC Therapeutics, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| EP-3889142-A1 | 1,2,4-OXADIAZOLE BENZOIC ACID COMPOUNDS AND THEIR USE FOR NONSENSE SUPPRESSION AND THE TREATMENT OF DISEASE | PTC Therapeutics, Inc. (US) | 2021-10-06 | — | — | EP | disclosed |