SCHEMBL2389452

SCHEMBL2389452

c1ccc(Nc2ccc3c(c2)Oc2ccc(Nc4ccccc4)cc2O3)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.56
HSD17B10 Q99714 5/20 0.56
TSHR P16473 4/20 0.56
TDP1 Q9NUW8 4/20 0.56
L3MBTL1 Q9Y468 4/20 0.56
ALOX12 P18054 3/20 0.56
ALOX15 P16050 2/20 0.56
PTGS1 P23219 1/20 0.56
SLC6A2 P23975 1/20 0.56
MAPK1 P28482 1/20 0.56
PTGS2 P35354 1/20 0.56
HTR2B P41595 1/20 0.56
MAPT P10636 5/20 0.56
MEN1 O00255 2/20 0.56
KMT2A Q03164 2/20 0.56
AR P10275 1/20 0.56
CYP3A4 P08684 5/20 0.52
HPGD P15428 2/20 0.52
LMNA P02545 3/20 0.47
GAA P10253 3/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22825075 0.98 ALDH1A1 (0.54) ALDH1A1HSD17B10TSHRTDP1L3MBTL1
SCHEMBL23281155 0.92 ALDH1A1 (0.60) ALDH1A1HSD17B10TSHRTDP1L3MBTL1
SCHEMBL23281215 0.91 AHR (0.52) ALDH1A1HSD17B10TSHRTDP1L3MBTL1
SCHEMBL18570306 0.88 ALDH1A1 (0.43) ALDH1A1HSD17B10TSHRTDP1L3MBTL1
SCHEMBL23168480 0.84 ALDH1A1 (0.50) ALDH1A1HSD17B10TSHRTDP1L3MBTL1
SCHEMBL3849254 0.83 ALDH1A1 (0.44) ALDH1A1HSD17B10TSHRTDP1L3MBTL1
SCHEMBL14535169 0.80 ALDH1A1 (0.54) ALDH1A1HSD17B10TSHRTDP1L3MBTL1
SCHEMBL16285335 0.80 ALDH1A1 (0.48) ALDH1A1HSD17B10TSHRTDP1L3MBTL1
SCHEMBL30008075 0.80 TRPV1 (0.43) ALDH1A1TSHRMAPK1MAPTMEN1
SCHEMBL24037162 0.78 ALDH1A1 (0.35) ALDH1A1HSD17B10TSHRTDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2984079-B1 HETEROCYCLIC COMPOUNDS AND THEIR USE IN ELECTRO-OPTICAL OR OPTO-ELECTRONIC DEVICES POWER OLEDS LTD (GB) 2020-07-01 EP disclosed
US-10439147-B2 Heterocyclic compounds and their use in electro-optical or opto-electronic devices POWER OLEDS LIMITED (GB) 2019-10-08 US disclosed
US-20180323378-A9 HETEROCYCLIC COMPOUNDS AND THEIR USE IN ELECTRO-OPTICAL OR OPTO-ELECTRONIC DEVICES POWER OLEDS LIMITED (GB) 2018-11-08 US disclosed
EP-2984079-A2 HETEROCYCLIC COMPOUNDS AND THEIR USE IN ELECTRO-OPTICAL OR OPTO-ELECTRONIC DEVICES Power Oleds Limited (GB) 2016-02-17 EP disclosed
US-20160035983-A1 HETEROCYCLIC COMPOUNDS AND THEIR USE IN ELECTRO-OPTICAL OR OPTO-ELECTRONIC DEVICES POWER OLEDS LTD (GB) 2016-02-04 US disclosed
WO-2014167286-A2 HETEROCYCLIC COMPOUNDS AND THEIR USE IN ELECTRO-OPTICAL OR OPTO-ELECTRONIC DEVICES POWER OLEDS LIMITED (GB) 2014-10-16 WO disclosed
US-8012606-B2 Heterocyclic compound and organic electroluminescent device using the same NIPPON STEEL CHEMICAL CO., LTD. (JP) 2011-09-06 US disclosed
US-8012606-B2 Heterocyclic compound and organic electroluminescent device using the same NIPPON STEEL CHEMICAL CO., LTD. (JP) 2011-09-06 US disclosed
US-8012606-B2 Heterocyclic compound and organic electroluminescent device using the same NIPPON STEEL CHEMICAL CO., LTD. (JP) 2011-09-06 US disclosed
US-7605277-B2 N,N'-Di(1-naphthyl)-N,N'-diphenyl-2,6-diaminodibenzodioxin; organic electroelement hole-transporting layer, light-emitting material, a host materialor dopant in the light-emitting layer,a hole-blocking layer, an electron-transporting layer;high luminous efficiency; high heat resistance; durability NIPPON STEEL CHEMICAL CO., LTD. (JP) 2009-10-20 US disclosed
US-7605277-B2 N,N'-Di(1-naphthyl)-N,N'-diphenyl-2,6-diaminodibenzodioxin; organic electroelement hole-transporting layer, light-emitting material, a host materialor dopant in the light-emitting layer,a hole-blocking layer, an electron-transporting layer;high luminous efficiency; high heat resistance; durability NIPPON STEEL CHEMICAL CO., LTD. (JP) 2009-10-20 US disclosed
US-20090153031-A1 Heterocyclic compound and organic electroluminescent device using the same NIPPON STEEL CHEMICAL CO., LTD (JP) 2009-06-18 US disclosed
US-20090153031-A1 Heterocyclic compound and organic electroluminescent device using the same NIPPON STEEL CHEMICAL CO., LTD (JP) 2009-06-18 US disclosed
US-20090153031-A1 Heterocyclic compound and organic electroluminescent device using the same NIPPON STEEL CHEMICAL CO., LTD (JP) 2009-06-18 US disclosed
US-20070129555-A1 Aminodibenzodioxin derivative and organic electroluminescent using the same NIPPON STEEL CHEMICAL & MATERIAL CO., LTD. (JP) 2007-06-07 US disclosed
US-20070129555-A1 Aminodibenzodioxin derivative and organic electroluminescent using the same NIPPON STEEL CHEMICAL & MATERIAL CO., LTD. (JP) 2007-06-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180323378-A9 HETEROCYCLIC COMPOUNDS AND THEIR USE IN ELECTRO-OPTICAL OR OPTO-ELECTRONIC DEVICES NAT1, SLCO2A1, SLCO2B1 ALDH1A1 789/4885HSD17B10 1935/4885TSHR 1859/4885
US-10439147-B2 Heterocyclic compounds and their use in electro-optical or opto-electronic devices NAT1, SLCO2A1, SLCO2B1 ALDH1A1 789/4885HSD17B10 1935/4885TSHR 1859/4885
US-20160035983-A1 HETEROCYCLIC COMPOUNDS AND THEIR USE IN ELECTRO-OPTICAL OR OPTO-ELECTRONIC DEVICES NAT1, SLCO2A1, SLCO2B1 ALDH1A1 789/4885HSD17B10 1935/4885TSHR 1859/4885
US-20090153031-A1 Heterocyclic compound and organic electroluminescent device using the same ORC3, NAP1L4, NR4A2 ALDH1A1 1372/4885HSD17B10 2706/4885TSHR 3293/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.