Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 5/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.46 |
| ▸ | EIF2AK3 | Q9NZJ5 | 10/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | EIF2AK1 | Q9BQI3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2374299 | 0.91 | CYP11B1 (0.47) | CYP11B1CYP11B2EIF2AK3RIPK1LCK | |
| SCHEMBL2373614 | 0.84 | EIF2AK3 (0.51) | CYP11B1CYP11B2EIF2AK3RIPK1LCK | |
| SCHEMBL868562 | 0.76 | EIF2AK3 (0.72) | EIF2AK3RIPK1LCKAURKBEIF2AK1 | |
| SCHEMBL869753 | 0.70 | EIF2AK3 (0.82) | EIF2AK3RIPK1LCKAURKBEIF2AK1 | |
| SCHEMBL870063 | 0.70 | RIPK1 (0.82) | EIF2AK3RIPK1 | |
| SCHEMBL2373766 | 0.70 | EIF2AK3 (0.48) | CYP11B1CYP11B2EIF2AK3RIPK1EIF2AK1 | |
| SCHEMBL868852 | 0.68 | EIF2AK3 (0.75) | EIF2AK3RIPK1LCKAURKBEIF2AK1 | |
| SCHEMBL13861301 | 0.67 | RIPK1 (0.52) | CYP11B1CYP11B2EIF2AK3RIPK1 | |
| SCHEMBL2374711 | 0.67 | EIF2AK3 (0.71) | CYP11B1CYP11B2EIF2AK3 | |
| SCHEMBL2373928 | 0.67 | RIPK1 (0.60) | EIF2AK3RIPK1LCKAURKBEIF2AK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011119663-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-09-29 | — | — | WO | disclosed |