Sugi Predict

Sugi Predict / Compounds / SCHEMBL23900367

SCHEMBL23900367

SCHEMBL23900367

O=C(COc1nc(=O)[nH]c(Cl)c1F)NC12CC3CC(CC(C3)C1)C2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDE3B Q13370 2/20 0.42
▸ PDE3A Q14432 2/20 0.42
▸ P2RY12 Q9H244 2/20 0.42
▸ PDE2A O00408 1/20 0.42
▸ ALDH1A1 P00352 12/20 0.42
▸ KMT2A Q03164 4/20 0.41
▸ MEN1 O00255 3/20 0.41
▸ LMNA P02545 3/20 0.41
▸ HTT P42858 2/20 0.41
▸ MAPT P10636 1/20 0.41
▸ NPSR1 Q6W5P4 1/20 0.41
▸ THRB P10828 1/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.41
▸ HPGD P15428 2/20 0.40
▸ TSHR P16473 1/20 0.40
▸ PTPRC P08575 1/20 0.39
▸ PTPN1 P18031 1/20 0.39
▸ PTPN11 Q06124 1/20 0.39
▸ PTPN13 Q12923 1/20 0.39
▸ PTPN22 Q9Y2R2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23900313 0.87 ALDH1A1 (0.46) PDE3BPDE3AP2RY12PDE2AALDH1A1
SCHEMBL23900437 0.86 ALDH1A1 (0.41) PDE3BPDE3AP2RY12PDE2AALDH1A1
SCHEMBL23884349 0.85 ALDH1A1 (0.42) PDE3BPDE3AP2RY12PDE2AALDH1A1
SCHEMBL23900320 0.84 PDE2A (0.30) PDE3BPDE3AP2RY12PDE2A
SCHEMBL23884290 0.83 PDE3B (0.42) PDE3BPDE3AP2RY12PDE2AALDH1A1
SCHEMBL23900300 0.82 ALDH1A1 (0.41) PDE3BPDE3AP2RY12PDE2AALDH1A1
SCHEMBL23900365 0.81 ALDH1A1 (0.38) PDE3BPDE3AP2RY12PDE2AALDH1A1
SCHEMBL23900368 0.80 ALDH1A1 (0.47) PDE3BPDE3AP2RY12PDE2AALDH1A1
SCHEMBL23900449 0.79 ALDH1A1 (0.45) PDE3BPDE3AP2RY12PDE2AALDH1A1
SCHEMBL23900438 0.79 ALDH1A1 (0.45) PDE3BPDE3AP2RY12PDE2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11566019-B2 2-pyrimidone analogs as potent antiviral agents against alphaviruses SOUTHERN RESEARCH INSTITUTE (US) 2023-01-31 — — US disclosed
US-20220177452-A9 2-Pyrimidone Analogs as Potent Antiviral Agents Against Alphaviruses NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2022-06-09 — — US disclosed
US-20210317106-A1 2-Pyrimidone Analogs as Potent Antiviral Agents Against Alphaviruses SOUTHERN RES INST (US) 2021-10-14 — — US disclosed
WO-2021203048-A1 NOVEL 2-PYRIMIDONE ANALOGS AS POTENT ANTIVIRAL AGENTS AGAINST ALPHAVIRUSES SOUTHERN RESEARCH INSTITUTE (US) 2021-10-07 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210317106-A1 2-Pyrimidone Analogs as Potent Antiviral Agents Against Alphaviruses EIF2AK2, ZC3HAV1, MAVS PDE3B 676/4885PDE3A 602/4885P2RY12 1335/4885
US-11566019-B2 2-pyrimidone analogs as potent antiviral agents against alphaviruses EIF2AK2, ZC3HAV1, MAVS PDE3B 676/4885PDE3A 602/4885P2RY12 1335/4885
US-20220177452-A9 2-Pyrimidone Analogs as Potent Antiviral Agents Against Alphaviruses EIF2AK2, ZC3HAV1, MAVS PDE3B 676/4885PDE3A 602/4885P2RY12 1335/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.