Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 3/20 | 0.47 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 5/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | PTAFR | P25105 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL23235851 | 0.99 | TOP2A (0.48) | TOP2ATOP2BALDH1A1RECQLF10 | |
| SCHEMBL23902282 | 0.86 | TOP2A (0.56) | TOP2ATOP2BALDH1A1RECQLF10 | |
| SCHEMBL23902315 | 0.85 | ALDH1A1 (0.36) | ALDH1A1RECQLF10CRHBPCRHR2 | |
| Hydrochloric Acid SCHEMBL23880710 | 0.85 | TOP2A (0.57) | TOP2ATOP2BALDH1A1RECQLF10 | |
| Hydrochloric Acid SCHEMBL23235772 | 0.84 | ALDH1A1 (0.35) | TOP2ATOP2BALDH1A1RECQLF10 | |
| SCHEMBL23901847 | 0.82 | ALDH1A1 (0.34) | ALDH1A1RECQLPTAFR | |
| Hydrochloric Acid SCHEMBL23235764 | 0.81 | ALDH1A1 (0.33) | ALDH1A1RECQLPTAFR | |
| SCHEMBL23902321 | 0.79 | TOP2A (0.45) | TOP2ATOP2BF10 | |
| SCHEMBL23901944 | 0.74 | TOP2A (0.51) | TOP2ATOP2BALDH1A1F10 | |
| SCHEMBL14029060 | 0.73 | TOP2A (0.77) | TOP2ATOP2BF10PTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210309641-A1 | AMIDINES AND AMIDINE ANALOGS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION ANTIBIOTICS | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2021-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210309641-A1 | AMIDINES AND AMIDINE ANALOGS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION ANTIBIOTICS | PAM, AMPD1, AMPD3 | TOP2A 405/4885TOP2B 1295/4885ALDH1A1 4745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.