SCHEMBL2390418

SCHEMBL2390418

CCNC(=O)[C@@H](C)NC(=O)OC(C)(C)C

nearest known ligand 0.69

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.56
CAPN1 P07384 1/20 0.50
CTSK P43235 9/20 0.49
CTSS P25774 6/20 0.49
CA1 P00915 1/20 0.49
CA2 P00918 1/20 0.49
CA7 P43166 1/20 0.49
CTSL P07711 1/20 0.47
CTSB P07858 1/20 0.47
GLS O94925 1/20 0.44
CYP2D6 P10635 1/20 0.44
ATM Q13315 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3010367 1.00 KMT2A (0.56) KMT2ACAPN1CTSKCTSSCA1
SCHEMBL13229651 0.88 CTSK (0.59) KMT2ACAPN1CTSKCTSSCA1
SCHEMBL8275379 0.88 CTSS (0.59) KMT2ACAPN1CTSKCTSSCA1
SCHEMBL24221821 0.86 KMT2A (0.53) KMT2ACAPN1CTSKCTSSCA1
SCHEMBL31517881 0.86 KMT2A (0.56) KMT2ACAPN1CTSKCTSSCA1
SCHEMBL6295388 0.84 KMT2A (0.55) KMT2ACAPN1CTSKCTSSCA1
SCHEMBL1022916 0.84 KMT2A (0.55) KMT2ACAPN1CTSKCTSSCA1
SCHEMBL25413150 0.84 KMT2A (0.55) KMT2ACAPN1CTSKCTSSCA1
SCHEMBL25413155 0.84 KMT2A (0.55) KMT2ACAPN1CTSKCTSSCA1
SCHEMBL13612436 0.84 KMT2A (0.55) KMT2ACAPN1CTSKCTSSCA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230113037-A1 [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES BAYER AKTIENGESELLSCHAFT (DE) 2023-04-13 US disclosed
US-20230113037-A1 [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES BAYER AKTIENGESELLSCHAFT (DE) 2023-04-13 US disclosed
EP-4013508-A1 [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES Bayer Aktiengesellschaft (DE) 2022-06-22 EP disclosed
CN-114466850-A [1,2,4] triazolo [1,5-C ] quinazolin-5-amines 拜耳股份有限公司 2022-05-10 CN disclosed
WO-2021028382-A1 [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES BAYER AKTIENGESELLSCHAFT (DE) 2021-02-18 WO disclosed
WO-2021028382-A1 [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES BAYER AKTIENGESELLSCHAFT (DE) 2021-02-18 WO disclosed
EP-3491922-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO Dow AgroSciences LLC (US) 2019-06-05 EP disclosed
US-20170158675-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO DOW AGROSCIENCES LLC (US) 2017-06-08 US disclosed
US-9622477-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC (US) 2017-04-18 US disclosed
US-9538756-B2 Pesticidal compositions and processes related thereto DOW AGROSCIENCES LLC (US) 2017-01-10 US disclosed
US-20110269960-A1 TRIAZOLE DERIVATIVE TAISHO PHARMACEUTICAL CO., LTD. (JP) 2011-11-03 US disclosed
US-20110269960-A1 TRIAZOLE DERIVATIVE TAISHO PHARMACEUTICAL CO., LTD. (JP) 2011-11-03 US disclosed
US-8022091-B2 Triazole derivative TAISHO PHARMACEUTICAL CO., LTD. (JP) 2011-09-20 US disclosed
US-8022091-B2 Triazole derivative TAISHO PHARMACEUTICAL CO., LTD. (JP) 2011-09-20 US disclosed
US-20100197749-A1 CHEMICAL COMPOUNDS ASTRAZENECA AB 2010-08-05 US disclosed
US-20100197749-A1 CHEMICAL COMPOUNDS ASTRAZENECA AB 2010-08-05 US disclosed
US-20100041655-A1 TRIAZOLE DERIVATIVE TAISHO PHARMACEUTICAL CO., LTD. (JP) 2010-02-18 US disclosed
US-20100041655-A1 TRIAZOLE DERIVATIVE TAISHO PHARMACEUTICAL CO., LTD. (JP) 2010-02-18 US disclosed
EP-1988083-A1 TRIAZOLE DERIVATIVE Taisho Pharmaceutical Co. Ltd. (JP) 2008-11-05 EP disclosed
WO-2007083089-A1 CHEMICAL COMPOUNDS ASTRAZENECA AB (SE) 2007-07-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100197749-A1 CHEMICAL COMPOUNDS EDF1, ECE1, EDNRA KMT2A 2713/4885CAPN1 3243/4885CTSK 3115/4885
US-20170158675-A1 PESTICIDAL COMPOSITIONS AND PROCESSES RELATED THERETO ACHE, DDT, PTMS KMT2A 3494/4885CAPN1 1104/4885CTSK 1143/4885
US-20110269960-A1 TRIAZOLE DERIVATIVE S1PR3, S1PR1, S1PR5 KMT2A 1641/4885CAPN1 4107/4885CTSK 3920/4885
US-20100041655-A1 TRIAZOLE DERIVATIVE S1PR3, S1PR1, S1PR5 KMT2A 1630/4885CAPN1 4121/4885CTSK 3910/4885
US-20230113037-A1 [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES AHR, HRH4, HRH1 KMT2A 919/4885CAPN1 4679/4885CTSK 2163/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.