SCHEMBL2390518

SCHEMBL2390518

CCOC(=O)c1c(N)[nH]c2cc(OC)c(OC)cc12

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.67
GAA P10253 5/20 0.67
KDM4E B2RXH2 4/20 0.67
HPGD P15428 4/20 0.67
NPSR1 Q6W5P4 2/20 0.67
LMNA P02545 2/20 0.61
L3MBTL1 Q9Y468 1/20 0.61
TUBB4A P04350 2/20 0.54
TUBB P07437 2/20 0.54
TUBA3C P0DPH7 2/20 0.54
TUBA1B P68363 2/20 0.54
TUBA4A P68366 2/20 0.54
TUBB4B P68371 2/20 0.54
TUBB3 Q13509 2/20 0.54
TUBB2A Q13885 2/20 0.54
TUBB8 Q3ZCM7 2/20 0.54
TUBA3E Q6PEY2 2/20 0.54
TUBA1A Q71U36 2/20 0.54
TUBA1C Q9BQE3 2/20 0.54
TUBB6 Q9BUF5 2/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18378421 0.91 LMNA (0.57) ALDH1A1GAAKDM4EHPGDNPSR1
SCHEMBL14301665 0.91 GAA (0.56) ALDH1A1GAAKDM4EHPGDNPSR1
SCHEMBL14296843 0.91 LMNA (0.57) ALDH1A1GAAKDM4EHPGDNPSR1
SCHEMBL18055550 0.90 LMNA (0.77) ALDH1A1GAAKDM4EHPGDNPSR1
SCHEMBL19593781 0.87 LMNA (0.54) ALDH1A1GAAKDM4EHPGDNPSR1
SCHEMBL19844865 0.85 LMNA (0.52) ALDH1A1GAAKDM4EHPGDNPSR1
SCHEMBL21501664 0.82 LMNA (0.48) ALDH1A1GAAKDM4EHPGDNPSR1
SCHEMBL4573958 0.81 KDM4E (0.54) ALDH1A1GAAKDM4EHPGDNPSR1
SCHEMBL5067366 0.81 ALDH1A1 (0.64) ALDH1A1GAAKDM4EHPGDLMNA
SCHEMBL14174310 0.81 KDM4E (1.00) ALDH1A1GAAKDM4EHPGDNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8999988-B2 Protein kinase inhibitors ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2015-04-07 US disclosed
US-8999988-B2 Protein kinase inhibitors ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2015-04-07 US disclosed
US-8999988-B2 Protein kinase inhibitors ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2015-04-07 US disclosed
US-20130302303-A1 PROTEIN KINASE INHIBITORS ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA 2013-11-14 US disclosed
US-20130302303-A1 PROTEIN KINASE INHIBITORS ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA 2013-11-14 US disclosed
US-20130302303-A1 PROTEIN KINASE INHIBITORS ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA 2013-11-14 US disclosed
US-8552018-B2 Substituted tricyclic compounds as protein kinase inhibitors ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2013-10-08 US disclosed
US-8552018-B2 Substituted tricyclic compounds as protein kinase inhibitors ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2013-10-08 US disclosed
US-8552018-B2 Substituted tricyclic compounds as protein kinase inhibitors ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2013-10-08 US disclosed
US-20110212929-A1 Protein Kinase Inhibitors ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA 2011-09-01 US disclosed
US-7312226-B2 Substituted tricyclic compounds as protein kinase inhibitors ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2007-12-25 US disclosed
US-7312226-B2 Substituted tricyclic compounds as protein kinase inhibitors ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2007-12-25 US disclosed
US-7312226-B2 Substituted tricyclic compounds as protein kinase inhibitors ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2007-12-25 US disclosed
WO-2006116733-A2 PROTEIN KINASE INHIBITORS SUPERGEN, INC. (US) 2006-11-02 WO disclosed
EP-1678166-A2 PROTEIN KINASE INHIBITORS Arizona Board of Regents on behalf of The University of Arizona (US) 2006-07-12 EP disclosed
US-20050277658-A1 Protein kinase inhibitors ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2005-12-15 US disclosed
US-20050239794-A1 Protein kinase inhibitors ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2005-10-27 US disclosed
US-20050239793-A1 Protein kinase inhibitors ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2005-10-27 US disclosed
US-20050227992-A1 Protein kinase inhibitors ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2005-10-13 US disclosed
WO-2005037825-A2 PROTEIN KINASE INHIBITORS ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2005-04-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050227992-A1 Protein kinase inhibitors CDK2, MAP3K1, MAP3K2 ALDH1A1 2994/4885GAA 3887/4885KDM4E 1499/4885
US-20050277658-A1 Protein kinase inhibitors CDK2, MAP3K1, MAP3K2 ALDH1A1 2994/4885GAA 3887/4885KDM4E 1499/4885
US-20050239794-A1 Protein kinase inhibitors CDK2, MAP3K1, MAP3K2 ALDH1A1 2994/4885GAA 3887/4885KDM4E 1499/4885
US-20050239793-A1 Protein kinase inhibitors CDK2, MAP3K1, MAP3K2 ALDH1A1 2994/4885GAA 3887/4885KDM4E 1499/4885
US-20130302303-A1 PROTEIN KINASE INHIBITORS CDK2, MAP3K1, MAP3K2 ALDH1A1 2994/4885GAA 3887/4885KDM4E 1499/4885
US-20110212929-A1 Protein Kinase Inhibitors CDK2, MAP3K1, MAP3K2 ALDH1A1 2994/4885GAA 3887/4885KDM4E 1499/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.