SCHEMBL23905726

SCHEMBL23905726

COc1cc(C(=O)NCC(O)(c2cc3c(c(-c4ccc(F)cc4)n2)OC[C@@]3(C#N)CF)C(F)(F)F)cc2cc(C#N)cnc12

nearest known ligand 0.52

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 3/20 0.32
IRAK4 Q9NWZ3 1/20 0.32
GABRA5 P31644 2/20 0.31
HPGDS O60760 1/20 0.31
GPR6 P46095 1/20 0.30
RET P07949 2/20 0.30
CFTR P13569 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23904699 0.93 RAF1 (0.32) GABRA5CFTR
SCHEMBL23904806 0.92 IRAK4 (0.33) BACE1IRAK4GABRA5HPGDSGPR6
SCHEMBL23905866 0.90 IRAK4 (0.32) BACE1IRAK4GABRA5HPGDSGPR6
SCHEMBL25116212 0.89 IRAK4 (0.32) BACE1IRAK4GABRA5HPGDSGPR6
SCHEMBL23905273 0.86 LRRK2 (0.33) IRAK4
SCHEMBL23905343 0.85 IP6K1 (0.31)
SCHEMBL23905272 0.85 IP6K1 (0.31)
SCHEMBL23905315 0.85 GABRA5 (0.34) GABRA5CFTR
SCHEMBL23905865 0.85 GABRA5 (0.34) GABRA5CFTR
SCHEMBL24988033 0.84 GABRA5 (0.35) GABRA5CFTR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021198981-A1 ANTIVIRAL COMPOUNDS AND USES THEREOF Janssen Biopharma, Inc. (US) 2021-10-07 WO disclosed