⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL573499 | 0.95 | ALDH1A1 (0.47) | — | |
| SCHEMBL26722615 | 0.93 | ALDH1A1 (0.50) | — | |
| SCHEMBL4842055 | 0.93 | ALDH1A1 (0.50) | — | |
| SCHEMBL20852085 | 0.93 | ALDH1A1 (0.50) | — | |
| SCHEMBL752095 | 0.90 | — | — | |
| SCHEMBL5466115 | 0.88 | — | — | |
| SCHEMBL2705709 | 0.82 | PLG (0.43) | — | |
| SCHEMBL25278102 | 0.80 | ALDH1A1 (0.41) | — | |
| SCHEMBL1543551 | 0.80 | MCL1 (0.39) | — | |
| SCHEMBL1013269 | 0.80 | MCL1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 162 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114085165-B | Cyano modified acrylic resin containing alpha-H, and preparation method and application thereof | 湖北中科博宏新材料科技有限公司 | 2024-01-09 | — | — | CN | claimed |
| CN-114085165-A | alpha-H-containing cyano modified acrylate resin and preparation method and application thereof | 新丰博兴聚合材料有限公司 | 2022-02-25 | — | — | CN | claimed |
| US-12383544-B2 | Methods for the treatment of polycystic kidney disease | GALAPAGOS NV (BE) | 2025-08-12 | — | — | US | disclosed |
| CN-119060018-A | N, N-diaryl urea derivative and application thereof | 杭州百新生物医药科技有限公司 | 2024-12-03 | — | — | CN | disclosed |
| EP-3958863-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF KIDNEY DISEASES | GALAPAGOS NV (BE) | 2024-07-03 | — | — | EP | disclosed |
| CN-114085165-B | Cyano modified acrylic resin containing alpha-H, and preparation method and application thereof | 湖北中科博宏新材料科技有限公司 | 2024-01-09 | — | — | CN | disclosed |
| CN-112812040-B | Amidine acylhydrazone compound and preparation method thereof | 赣南师范大学 | 2023-03-31 | — | — | CN | disclosed |
| US-20220202802-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF KIDNEY DISEASES | GALAPAGOS NV (BE) | 2022-06-30 | — | — | US | disclosed |
| CN-114401722-A | Inhibitors of tyrosine kinases | 布里奇恩生物科学公司 | 2022-04-26 | — | — | CN | disclosed |
| EP-3958863-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF KIDNEY DISEASES | Galapagos N.V. (BE) | 2022-03-02 | — | — | EP | disclosed |
| CN-114085165-A | alpha-H-containing cyano modified acrylate resin and preparation method and application thereof | 新丰博兴聚合材料有限公司 | 2022-02-25 | — | — | CN | disclosed |
| EP-1487435-A1 | AZETIDINE DERIVATIVES AS CCR-3 RECEPTOR ANTAGONISTS | Novartis AG (CH) | 2004-12-22 | — | — | EP | disclosed |
| CN-1518543-A | Pyrazole derivatives and their use as protein kinase inhibitors | �Ʒ� | 2004-08-04 | — | — | CN | disclosed |
| WO-2003077907-A1 | AZETIDINE DERIVATIVES AS CCR-3 RECEPTOR ANTAGONISTS | NOVARTIS AG (CH) | 2003-09-25 | — | — | WO | disclosed |
| EP-1313710-A1 | PYRAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | Pfizer Products Inc. (US) | 2003-05-28 | — | — | EP | disclosed |
| US-20020103185-A1 | Pyrazole derivatives | PFIZER PRODUCTS INC. | 2002-08-01 | — | — | US | disclosed |
| WO-2002018346-A1 | PYRAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2002-03-07 | — | — | WO | disclosed |
| EP-0326107-B1 | ANTIARTHRITIC BETA-CYCLOALKYL-BETA-OXOPROPIONITRILES | Bristol-Myers Squibb Company (US) | 1992-09-02 | — | — | EP | disclosed |
| US-4888357-A | ANTIINFLAMMATORY AGENTS | BRISTOL-MYERS COMPANY (US) | 1989-12-19 | — | — | US | disclosed |
| EP-0326107-A1 | Antiarthritic beta-cycloalkyl-beta-oxopropionitriles | Bristol-Myers Squibb Company (US) | 1989-08-02 | — | — | EP | disclosed |