SCHEMBL23911531

SCHEMBL23911531

C[Si](C)(C)OCc1cc2nccc(Cl)c2s1

nearest known ligand 0.33

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
KMT2A Q03164 2/20 0.32
MEN1 O00255 1/20 0.32
USP7 Q93009 4/20 0.31
L3MBTL1 Q9Y468 2/20 0.31
TDP1 Q9NUW8 1/20 0.31
LMNA P02545 1/20 0.30
POLB P06746 1/20 0.30
RAB9A P51151 1/20 0.30
ATM Q13315 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26915789 0.86 LMNA (0.33) CYP1A2CYP2C9CYP2C19L3MBTL1LMNA
SCHEMBL23910824 0.81 LMNA (0.31) L3MBTL1LMNAPOLBRAB9AATM
SCHEMBL23666994 0.79 KDM4E (0.32) USP7LMNARAB9A
SCHEMBL29997769 0.79 KDM4E (0.32) USP7LMNARAB9A
SCHEMBL25282439 0.78 LOXL2 (0.38) USP7
SCHEMBL1850156 0.78 USP7 (0.40) USP7
SCHEMBL25739758 0.78 USP7 (0.31) USP7
SCHEMBL5245172 0.77 CYP2A6 (0.41) CYP2C19USP7
SCHEMBL26915647 0.75
SCHEMBL23911563 0.75 MAPKAPK2 (0.34) USP7RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210317134-A1 UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF RAPT THERAPEUTICS INC (US) 2021-10-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210317134-A1 UBIQUITIN-SPECIFIC-PROCESSING PROTEASE 7 (USP7) MODULATORS AND USES THEREOF USP7, SENP7, USP8 CYP1A2 3993/4885CYP2C9 4496/4885CYP2C19 4580/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.