Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | DRD1 | P21728 | 4/20 | 0.43 |
| ▸ | DRD5 | P21918 | 4/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17458293 | 0.82 | HDAC1 (0.47) | HDAC1HDAC8HDAC6PIK3CDPIK3R1 | |
| SCHEMBL17458291 | 0.82 | HDAC1 (0.47) | HDAC1HDAC8HDAC6PIK3CDPIK3R1 | |
| SCHEMBL23912298 | 0.79 | HDAC1 (0.52) | HDAC1HDAC8HDAC6PIK3CDPIK3R1 | |
| SCHEMBL20404285 | 0.79 | HDAC1 (0.50) | HDAC1HDAC8HDAC6PIK3CDPIK3R1 | |
| SCHEMBL23912240 | 0.77 | PIK3CD (0.55) | HDAC6DRD1DRD5PDE7APIK3CD | |
| SCHEMBL17461948 | 0.76 | PIK3CD (0.43) | HDAC1HDAC8HDAC6PIK3CDPIK3R1 | |
| SCHEMBL20404396 | 0.76 | PIK3CD (0.57) | PIK3CDPIK3R1SMN1; SMN2ALDH1A1KCNH2 | |
| SCHEMBL19916811 | 0.75 | HDAC1 (0.51) | HDAC1HDAC8HDAC6PIK3CDPIK3R1 | |
| SCHEMBL16597182 | 0.71 | SMN1; SMN2 (0.50) | PIK3CDPIK3R1SMN1; SMN2ALDH1A1KCNH2 | |
| SCHEMBL16597185 | 0.71 | PDE10A (0.52) | PIK3CDPIK3R1SMN1; SMN2ALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160960-B1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES INC (US) | 2021-10-13 | — | — | EP | disclosed |