Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.55 |
| ▸ | DRD1 | P21728 | 3/20 | 0.43 |
| ▸ | DRD5 | P21918 | 3/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17458295 | 0.85 | PIK3CD (0.67) | PIK3CDPDE7APIK3CBPIK3CGHDAC6 | |
| SCHEMBL17458292 | 0.85 | PIK3CD (0.67) | PIK3CDPDE7APIK3CBPIK3CGHDAC6 | |
| SCHEMBL17458223 | 0.82 | PIK3CD (0.65) | PIK3CDPIK3CBPIK3CGHDAC6 | |
| SCHEMBL23912237 | 0.82 | HRH3 (0.59) | PIK3CDKCNH2HRH3 | |
| SCHEMBL23912253 | 0.78 | SMN1; SMN2 (0.45) | PIK3CDKCNH2HRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL23912247 | 0.77 | HDAC1 (0.46) | PIK3CDDRD1DRD5PDE7AKCNH2 | |
| SCHEMBL23912243 | 0.77 | PIK3CD (0.50) | PIK3CDKCNH2HRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL23912265 | 0.77 | PIK3CD (0.56) | PIK3CDKCNH2HRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL20404284 | 0.77 | SMN1; SMN2 (0.48) | PIK3CDKCNH2HRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL20404396 | 0.77 | PIK3CD (0.57) | PIK3CDKCNH2HRH3ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160960-B1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES INC (US) | 2021-10-13 | — | — | EP | disclosed |