Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 5/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.49 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.49 |
| ▸ | STK3 | Q13188 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.49 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14784319 | 0.80 | METAP2 (1.00) | METAP2ERBB2ERBB4AURKAROCK2 | |
| SCHEMBL10268908 | 0.79 | METAP2 (0.72) | METAP2ERBB2ERBB4AURKAROCK2 | |
| SCHEMBL30136942 | 0.77 | METAP2 (0.52) | METAP2ERBB2ERBB4AURKAROCK2 | |
| SCHEMBL28237558 | 0.75 | METAP2 (0.66) | METAP2ERBB2ERBB4AURKAROCK2 | |
| SCHEMBL261171 | 0.74 | NOS1 (0.55) | METAP2NOS1AXLIDO1BRAF | |
| SCHEMBL29575075 | 0.74 | NOS1 (0.55) | METAP2NOS1AXLIDO1BRAF | |
| SCHEMBL16406546 | 0.74 | PIK3CD (0.58) | PIK3CDPIK3CBABL1 | |
| SCHEMBL27650245 | 0.73 | NOS1 (0.53) | METAP2NOS1AXLIDO1BRAF | |
| SCHEMBL30144924 | 0.72 | METAP2 (0.67) | METAP2ERBB2ERBB4AURKAROCK2 | |
| SCHEMBL29614992 | 0.72 | METAP2 (0.61) | METAP2ERBB2ERBB4AURKAROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3892278-A1 | CYCLOALKANE-1,3-DIAMINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2021-10-13 | — | — | EP | disclosed |