Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 6/20 | 0.66 |
| ▸ | AXL | P30530 | 2/20 | 0.57 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14784319 | 0.80 | METAP2 (1.00) | METAP2AXLBRD4AURKAROCK2 | |
| SCHEMBL10268908 | 0.79 | METAP2 (0.72) | METAP2AXLBRD4AURKAROCK2 | |
| SCHEMBL28237613 | 0.76 | AXL (0.73) | METAP2AXLTRPV1TRPA1 | |
| SCHEMBL23912315 | 0.75 | METAP2 (0.66) | METAP2AXLBRD4AURKAROCK2 | |
| SCHEMBL7090984 | 0.74 | PIK3CD (0.63) | EPHX2 | |
| SCHEMBL15229812 | 0.74 | METAP2 (1.00) | METAP2CYP1A2 | |
| SCHEMBL12683720 | 0.73 | AXL (1.00) | METAP2AXLTRPV1TRPA1NOS1 | |
| SCHEMBL15230510 | 0.73 | METAP2 (0.76) | METAP2CDK2CCNA1CYP1A2FLT3 | |
| SCHEMBL30144924 | 0.72 | METAP2 (0.67) | METAP2AXLCDK2CCNA1BRD4 | |
| SCHEMBL29614992 | 0.72 | METAP2 (0.61) | METAP2AXLBRD4AURKAROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105683194-B | The inhibitor of (azepine) pyrido PyrazolopyrimidinonecGMP and indazole hepyramine as fibrinolysis | 拜耳制药股份公司 | 2018-09-14 | — | — | CN | disclosed |