SCHEMBL23912787

SCHEMBL23912787

COc1cc(C)ccc1SCl

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.56
ALDH1A1 P00352 3/20 0.45
CYP3A4 P08684 2/20 0.45
L3MBTL1 Q9Y468 9/20 0.43
MAPT P10636 8/20 0.43
HPGD P15428 6/20 0.43
CYP2C9 P11712 3/20 0.43
CYP2C19 P33261 3/20 0.43
MAPK1 P28482 2/20 0.43
MEN1 O00255 1/20 0.43
USP2 O75604 1/20 0.43
POLB P06746 1/20 0.43
ALOX12 P18054 1/20 0.43
KMT2A Q03164 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
HTR1A P08908 2/20 0.42
HTR3A P46098 2/20 0.42
TDP1 Q9NUW8 2/20 0.41
GAA P10253 2/20 0.41
ALOX15 P16050 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9914231 0.81 ACHE (0.58) ACHEALDH1A1CYP3A4L3MBTL1MAPT
SCHEMBL9018791 0.79 MAPT (0.38) ACHEALDH1A1L3MBTL1MAPTHPGD
SCHEMBL2874102 0.78 KDM4E (0.39) ALDH1A1L3MBTL1MAPTPOLBTDP1
SCHEMBL3783961 0.78 MAPT (0.50) ALDH1A1CYP3A4L3MBTL1MAPTHPGD
SCHEMBL23912802 0.78 IDO1 (0.39) L3MBTL1MAPTMEN1KMT2AKDM4E
SCHEMBL31345541 0.76 MAPT (0.63) ACHEALDH1A1CYP3A4L3MBTL1MAPT
SCHEMBL26717551 0.76 ACHE (0.52) ACHEALDH1A1CYP3A4L3MBTL1MAPT
SCHEMBL11822275 0.75 TP53 (0.44) ACHEALDH1A1CYP3A4MAPTHPGD
SCHEMBL2023201 0.73 TP53 (0.48) ALDH1A1CYP3A4MAPTHPGDCYP2C9
SCHEMBL24457920 0.72 GAA (0.52) ALDH1A1CYP3A4MAPTHPGDCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3094325-B1 HETEROARYLS AND USES THEREOF TAKEDA PHARMACEUTICALS CO (JP) 2021-10-13 EP disclosed