Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.50 |
| ▸ | DPP4 | P27487 | 1/20 | 0.50 |
| ▸ | FDPS | P14324 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 3/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 3/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2390189 | 0.88 | TTR (0.52) | TTRDPP4FDPSMAOBCYP3A4 | |
| SCHEMBL2387614 | 0.86 | TTR (0.50) | TTRDPP4FDPSMAOBCYP3A4 | |
| SCHEMBL2391253 | 0.86 | CYP3A4 (0.46) | TTRDPP4FDPSMAOBCYP3A4 | |
| SCHEMBL6022894 | 0.84 | KDM4E (0.48) | TTRDPP4CYP3A4CA12CA1 | |
| SCHEMBL6022895 | 0.84 | KDM4E (0.48) | TTRDPP4CYP3A4CA12CA1 | |
| SCHEMBL12309929 | 0.83 | FDPS (0.47) | TTRDPP4FDPSMAOBCYP3A4 | |
| SCHEMBL22000637 | 0.80 | FDPS (0.70) | TTRDPP4FDPSMAOBCYP3A4 | |
| SCHEMBL2392289 | 0.80 | KDM4E (0.52) | TTRDPP4FDPSMAOBCYP3A4 | |
| SCHEMBL27537154 | 0.80 | KDM4E (0.52) | TTRDPP4FDPSMAOBCYP3A4 | |
| SCHEMBL7247668 | 0.80 | FDPS (0.53) | TTRFDPSMAOBAPPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE42700-E1 | Induction of apoptosis in cancer cells | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-09-13 | — | — | US | disclosed |
| US-RE42700-E1 | Induction of apoptosis in cancer cells | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-09-13 | — | — | US | disclosed |