Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | WNT1 | P04628 | 5/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.41 |
| ▸ | CLK2 | P49760 | 2/20 | 0.41 |
| ▸ | CLK3 | P49761 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.40 |
| ▸ | HPGD | P15428 | 8/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23048622 | 0.86 | ALDH1A1 (0.43) | HRH4WNT1DYRK1ACLK2CLK3 | |
| SCHEMBL19546591 | 0.84 | HRH4 (0.56) | HRH4ALDH1A1HSD17B10HPGDUSP2 | |
| SCHEMBL23048818 | 0.77 | DYRK1A (0.42) | HRH4WNT1DYRK1AALDH1A1HSD17B10 | |
| SCHEMBL23048624 | 0.75 | DYRK1A (0.39) | HRH4WNT1DYRK1AALDH1A1HSD17B10 | |
| SCHEMBL19547082 | 0.73 | HRH4 (0.54) | HRH4TSHRSMN1; SMN2CYP1A2 | |
| SCHEMBL19546944 | 0.71 | OGA (0.40) | HRH4ALDH1A1TSHRKDM4EL3MBTL1 | |
| SCHEMBL19546973 | 0.71 | HRH3 (0.43) | HRH4WNT1DYRK1AGSK3BALDH1A1 | |
| SCHEMBL23916232 | 0.71 | HRH4 (0.39) | HRH4KDM4ERAD52UBE2NL3MBTL1 | |
| SCHEMBL19547056 | 0.71 | HRH4 (0.55) | HRH4ALDH1A1HSD17B10CYP2D6CYP1A2 | |
| SCHEMBL23916706 | 0.70 | PTPN11 (0.41) | HRH4KDM4EHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3892276-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AS WNT INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |