Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 5/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.33 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.31 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.31 |
| ▸ | SORD | Q00796 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19546591 | 0.75 | HRH4 (0.56) | HRH4HRH3GAAMAPTKDM4E | |
| SCHEMBL19546754 | 0.74 | HRH4 (0.54) | HRH4HRH3 | |
| SCHEMBL19547082 | 0.73 | HRH4 (0.54) | HRH4MAPTRAB9APOLB | |
| SCHEMBL19546944 | 0.72 | OGA (0.40) | HRH4OPRD1MAPTKDM4E | |
| SCHEMBL19546962 | 0.72 | HRH3 (0.43) | HRH3ADRA1DADRA1AADRA1B | |
| SCHEMBL23916232 | 0.72 | HRH4 (0.39) | HRH4SORDHRH3GRIN2DGRIN3B | |
| SCHEMBL19546973 | 0.72 | HRH3 (0.43) | HRH4SORDHRH3MAPTKDM4E | |
| SCHEMBL23916630 | 0.71 | WNT1 (0.40) | HRH4MAPTKDM4EPOLB | |
| SCHEMBL23916092 | 0.70 | HRH4 (0.42) | HRH4HRH3KDM4E | |
| SCHEMBL19546959 | 0.69 | HRH4 (0.38) | HRH4SORDHRH3GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3892276-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AS WNT INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |