Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.49 |
| ▸ | CLK1 | P49759 | 2/20 | 0.49 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.49 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | SRC | P12931 | 4/20 | 0.45 |
| ▸ | ABL1 | P00519 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | ABL2 | P42684 | 3/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.45 |
| ▸ | PRKACA | P17612 | 3/20 | 0.45 |
| ▸ | CLK2 | P49760 | 3/20 | 0.45 |
| ▸ | GSK3A | P49840 | 3/20 | 0.45 |
| ▸ | GSK3B | P49841 | 3/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.45 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2073031 | 0.92 | LCK (0.54) | LRRK2DYRK1ADYRK1BCLK1DYRK2 | |
| SCHEMBL24710755 | 0.87 | LRRK2 (0.51) | LRRK2DYRK1ADYRK1BCLK1DYRK2 | |
| SCHEMBL8107167 | 0.84 | FLT3 (0.46) | LRRK2DYRK1ADYRK1BFLT3SRC | |
| SCHEMBL4352960 | 0.84 | LRRK2 (0.58) | LRRK2DYRK1ADYRK1BFLT3PRKD3 | |
| SCHEMBL3787081 | 0.84 | SRC (0.50) | LRRK2DYRK1ADYRK1BFLT3SRC | |
| SCHEMBL1896766 | 0.84 | STK3 (0.58) | LRRK2DYRK1ADYRK1BFLT3SRC | |
| SCHEMBL7021288 | 0.83 | LRRK2 (0.63) | LRRK2DYRK1ADYRK1BFLT3SRC | |
| SCHEMBL28057752 | 0.82 | RET (0.48) | LRRK2DYRK1ADYRK1BFLT3PRKD3 | |
| SCHEMBL12438584 | 0.82 | LRRK2 (0.55) | LRRK2FLT3SRCABL1EGFR | |
| SCHEMBL4350812 | 0.80 | KDR (0.57) | LRRK2DYRK1AFLT3SRCABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | MEDIVATION TECHNOLOGIES, INC. (US) | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | BTK, PIK3CD, PIK3CB | LRRK2 684/4885DYRK1A 449/4885DYRK1B 387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.