Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.58 |
| ▸ | STK3 | Q13188 | 3/20 | 0.58 |
| ▸ | STK4 | Q13043 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.47 |
| ▸ | MET | P08581 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 3/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24710755 | 0.87 | LRRK2 (0.51) | LRRK2STK3STK4PTK2BPDPK1 | |
| SCHEMBL8107167 | 0.84 | FLT3 (0.46) | LRRK2STK3STK4PTK2BPDPK1 | |
| SCHEMBL1896766 | 0.84 | STK3 (0.58) | LRRK2STK3STK4HPGDPTK2B | |
| SCHEMBL23917432 | 0.84 | LRRK2 (0.50) | LRRK2STK3PTK2BPDPK1AXL | |
| SCHEMBL3787081 | 0.84 | SRC (0.50) | LRRK2STK3STK4PDPK1AXL | |
| SCHEMBL7021288 | 0.83 | LRRK2 (0.63) | LRRK2STK3STK4PTK2BPDPK1 | |
| SCHEMBL8107173 | 0.83 | FLT3 (0.46) | LRRK2STK3STK4PTK2BPDPK1 | |
| SCHEMBL28057752 | 0.82 | RET (0.48) | LRRK2STK3STK4PTK2BPDPK1 | |
| SCHEMBL31531349 | 0.82 | FLT3 (0.51) | LRRK2STK3STK4PDPK1MET | |
| SCHEMBL4353306 | 0.82 | LRRK2 (0.62) | LRRK2STK3STK4JAK3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009070328-A1 | MODULATORS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) PATHWAY FOR USE IN THE TREATMENT OR PREVENTION OF SUBSTANCE ABUSE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-04 | — | — | WO | disclosed |
| US-6051577-A | TYROSINE INHIBITORS; BONE DISORDERS | NOVARTIS AG (CH) | 2000-04-18 | — | — | US | disclosed |
| EP-0888353-A1 | NOVEL N-7-HETEROCYCLYL PYRROLO 2,3-D]PYRIDINES AND THEIR USE | Novartis AG (CH) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997034895-A1 | NOVEL N-7-HETEROCYCLYL PYRROLO[2,3-D]PYRIDINES AND THEIR USE | NOVARTIS AG (CH) | 1997-09-25 | — | — | WO | disclosed |
| WO-1997032879-A1 | 7-ALKYL-PYRROLO[2,3-d]PYRIMIDINES | NOVARTIS AG (CH) | 1997-09-12 | — | — | WO | disclosed |