Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.38 |
| ▸ | ABL1 | P00519 | 7/20 | 0.38 |
| ▸ | EGFR | P00533 | 7/20 | 0.38 |
| ▸ | HCK | P08631 | 7/20 | 0.38 |
| ▸ | SRC | P12931 | 7/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.38 |
| ▸ | MTOR | P42345 | 7/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.38 |
| ▸ | PRKDC | P78527 | 7/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 6/20 | 0.38 |
| ▸ | CSF1R | P07333 | 7/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.37 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23917272 | 0.81 | LIMK1 (0.47) | KDRPI4KBABL1EGFRSRC | |
| SCHEMBL23917259 | 0.78 | EGFR (0.46) | KDRPI4KBPIK3CDABL1EGFR | |
| SCHEMBL16655686 | 0.73 | PIK3CD (0.41) | KDRPI4KBPIK3CDABL1EGFR | |
| SCHEMBL3490619 | 0.65 | LIMK1 (0.44) | KDRPI4KBLIMK1PI4KAPI4K2B | |
| SCHEMBL29178941 | 0.65 | ESR1 (0.41) | KDRPI4KBPIK3CDABL1EGFR | |
| SCHEMBL16655086 | 0.65 | PIK3CD (0.45) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL8820773 | 0.64 | PIK3CD (0.41) | KDRPI4KBPIK3CDABL1EGFR | |
| SCHEMBL28474962 | 0.64 | LIMK1 (0.39) | KDRPI4KBLIMK1PI4KAPI4K2B | |
| SCHEMBL23283552 | 0.62 | METTL3 (0.55) | KDRABL1EGFRSRC | |
| SCHEMBL8819936 | 0.62 | SRC (0.35) | KDRPI4KBPIK3CDABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | MEDIVATION TECHNOLOGIES, INC. (US) | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | BTK, PIK3CD, PIK3CB | KDR 858/4885PI4KB 10/4885PIK3CD 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.