Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.67 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | KEAP1 | Q14145 | 7/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.52 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2398328 | 0.87 | GRM5 (0.62) | GRM5NOTUMCA12CA1CA2 | |
| SCHEMBL2394342 | 0.87 | GRM5 (0.56) | GRM5NOTUMCA12CA1CA2 | |
| SCHEMBL28414073 | 0.83 | GRM5 (0.58) | GRM5NOTUMCA12CA1CA2 | |
| SCHEMBL29657622 | 0.83 | GRM5 (0.58) | GRM5NOTUMCA12CA1CA2 | |
| SCHEMBL1847996 | 0.82 | GRM5 (0.60) | GRM5NOTUMCA12CA1CA2 | |
| SCHEMBL5201985 | 0.81 | GRM5 (1.00) | GRM5NOTUMCA12CA1CA2 | |
| SCHEMBL5201644 | 0.80 | GRM5 (0.67) | GRM5GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL19700914 | 0.79 | HDAC2 (0.48) | GRM5NOTUMGABRG2GABRB3GABRA5 | |
| SCHEMBL29946187 | 0.78 | STIM1 (0.68) | GRM5NOTUMCA12CA1CA2 | |
| SCHEMBL26628279 | 0.78 | STIM1 (0.68) | GRM5NOTUMCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212999-A1 | TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2011-09-01 | — | — | US | claimed |
| CN-102131797-A | Triazole derivatives and their use as nicotinic acetylcholine receptor modulators | NEUROSEARCH AS | 2011-07-20 | — | — | CN | claimed |
| EP-2324007-B1 | TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH AS (DK) | 2012-08-15 | — | — | EP | disclosed |
| US-20110212999-A1 | TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2011-09-01 | — | — | US | disclosed |
| CN-102131797-A | Triazole derivatives and their use as nicotinic acetylcholine receptor modulators | NEUROSEARCH AS | 2011-07-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212999-A1 | TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | CHRNA3, CHRNA5, CHRNB3 | GRM5 148/4885NOTUM 935/4885CA12 4138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.