Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.56 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.54 |
| ▸ | CHRNA5 | P30532 | 2/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.54 |
| ▸ | MIF | P14174 | 1/20 | 0.51 |
| ▸ | OXTR | P30559 | 1/20 | 0.50 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2398328 | 0.90 | GRM5 (0.62) | GRM5CHRNB2CHRNA5CHRNA4MIF | |
| SCHEMBL2391955 | 0.87 | GRM5 (0.67) | GRM5NOTUMCA12CA1CA2 | |
| SCHEMBL1959449 | 0.81 | GRM5 (0.60) | GRM5CHRNB2CHRNA5CHRNA4OXTR | |
| SCHEMBL2394519 | 0.81 | MIF (0.73) | GRM5CHRNB2CHRNA5CHRNA4MIF | |
| SCHEMBL16658972 | 0.81 | FLT3 (0.65) | MIFNOTUMCA12CA9FLT3 | |
| SCHEMBL16220807 | 0.80 | MIF (0.62) | CHRNB2CHRNA5CHRNA4MIFCA12 | |
| SCHEMBL27719702 | 0.79 | GRM5 (0.56) | GRM5CHRNB2CHRNA5CHRNA4OXTR | |
| SCHEMBL12827347 | 0.78 | CHRNB2 (0.58) | GRM5CHRNB2CHRNA5CHRNA4MIF | |
| SCHEMBL16658968 | 0.78 | KEAP1 (0.58) | MIFNOTUMCA12CA1CA2 | |
| SCHEMBL16658973 | 0.78 | KEAP1 (0.58) | GRM5MIFCA1CA2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212999-A1 | TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2011-09-01 | — | — | US | claimed |
| CN-102131797-A | Triazole derivatives and their use as nicotinic acetylcholine receptor modulators | NEUROSEARCH AS | 2011-07-20 | — | — | CN | claimed |
| US-20110212999-A1 | TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2011-09-01 | — | — | US | disclosed |
| CN-102131797-A | Triazole derivatives and their use as nicotinic acetylcholine receptor modulators | NEUROSEARCH AS | 2011-07-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212999-A1 | TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | CHRNA3, CHRNA5, CHRNB3 | GRM5 148/4885CHRNB2 14/4885CHRNA5 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.