Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 2/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.44 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2391955 | 0.82 | GRM5 (0.67) | GRM5CA12CA1CA2CA9 | |
| SCHEMBL27812070 | 0.81 | GRM5 (0.58) | GRM5NOTUMKDM4EALDH1A1MAPT | |
| SCHEMBL2398328 | 0.81 | GRM5 (0.62) | GRM5CA12CA1CA2CA9 | |
| SCHEMBL29657622 | 0.80 | GRM5 (0.58) | GRM5CA12CA1CA2CA9 | |
| SCHEMBL28414073 | 0.80 | GRM5 (0.58) | GRM5CA12CA1CA2CA9 | |
| SCHEMBL2120644 | 0.76 | CHRNB2 (0.67) | GRM5MAPT | |
| SCHEMBL1849083 | 0.76 | GRM5 (0.67) | GRM5CA12CA1CA2CA9 | |
| Hydrochloric Acid SCHEMBL3719278 | 0.75 | CHRNB2 (0.66) | GRM5MAPT | |
| SCHEMBL5201985 | 0.75 | GRM5 (1.00) | GRM5CA12CA1CA2CA9 | |
| SCHEMBL2394342 | 0.73 | GRM5 (0.56) | GRM5CA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212999-A1 | TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2011-09-01 | — | — | US | claimed |
| CN-102131797-A | Triazole derivatives and their use as nicotinic acetylcholine receptor modulators | NEUROSEARCH AS | 2011-07-20 | — | — | CN | claimed |
| EP-2324007-A1 | TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NeuroSearch A/S (DK) | 2011-05-25 | — | — | EP | claimed |
| WO-2010026134-A1 | TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2010-03-11 | — | — | WO | claimed |
| EP-2324007-B1 | TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH AS (DK) | 2012-08-15 | — | — | EP | disclosed |
| US-20110212999-A1 | TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | NEUROSEARCH A/S (DK) | 2011-09-01 | — | — | US | disclosed |
| CN-102131797-A | Triazole derivatives and their use as nicotinic acetylcholine receptor modulators | NEUROSEARCH AS | 2011-07-20 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212999-A1 | TRIAZOLE DERIVATIVES AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | CHRNA3, CHRNA5, CHRNB3 | GRM5 148/4885CA12 4138/4885CA1 3807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.