Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 7/20 | 0.48 |
| ▸ | ACACA | Q13085 | 5/20 | 0.48 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.47 |
| ▸ | ATF4 | P18848 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28720402 | 1.00 | ACACB (0.48) | ACACBACACAPBKATF4RAB9A | |
| SCHEMBL29527421 | 1.00 | ACACB (0.48) | ACACBACACAPBKATF4RAB9A | |
| SCHEMBL29527441 | 1.00 | ACACB (0.48) | ACACBACACAPBKATF4RAB9A | |
| SCHEMBL21050155 | 0.90 | RAB9A (0.51) | ATF4RAB9ANPC1HDAC3HDAC1 | |
| SCHEMBL21050159 | 0.90 | RAB9A (0.51) | ATF4RAB9ANPC1HDAC3HDAC1 | |
| SCHEMBL29356799 | 0.90 | RAB9A (0.51) | ATF4RAB9ANPC1HDAC3HDAC1 | |
| SCHEMBL22373836 | 0.87 | ACACB (0.43) | ACACBACACAATF4HDAC3HDAC1 | |
| SCHEMBL22777444 | 0.87 | RAB9A (0.54) | ATF4RAB9ANPC1HDAC3HDAC1 | |
| SCHEMBL22777445 | 0.87 | RAB9A (0.54) | ATF4RAB9ANPC1HDAC3HDAC1 | |
| SCHEMBL29447009 | 0.87 | RAB9A (0.54) | ATF4RAB9ANPC1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210317102-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ALTOS LABS, INC. | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317102-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | ACACB 862/4885ACACA 1961/4885PBK 4099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.