SCHEMBL23920871

SCHEMBL23920871

Cc1[nH]c2nc3c(nc(Br)n3CCO)c(=O)n2c1-c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.40
MAPT P10636 2/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
RAB9A P51151 2/20 0.40
LMNA P02545 1/20 0.40
POLB P06746 1/20 0.40
ADORA3 P0DMS8 4/20 0.39
TP53 P04637 1/20 0.37
TSHR P16473 1/20 0.37
GAA P10253 1/20 0.36
ADORA1 P30542 2/20 0.36
ADORA2A P29274 1/20 0.36
ADORA2B P29275 1/20 0.36
ALDH1A1 P00352 3/20 0.35
HPGD P15428 2/20 0.35
RXFP1 Q9HBX9 1/20 0.35
DHODH Q02127 1/20 0.34
CYP2C9 P11712 2/20 0.34
CYP1A2 P05177 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21396535 0.85 ADORA3 (0.39) KDM4EMAPTMEN1KMT2ARAB9A
SCHEMBL23920943 0.78 ALDH1A1 (0.36) KDM4EMAPTMEN1KMT2ARAB9A
SCHEMBL23921240 0.77 ADORA3 (0.51) ADORA3TP53ADORA1ADORA2AADORA2B
SCHEMBL21396504 0.71 ADORA3 (0.42) KDM4ERAB9ALMNAADORA3TP53
SCHEMBL23921016 0.69 ADORA3 (0.40) ADORA3TP53ADORA1ADORA2AADORA2B
SCHEMBL21396379 0.69 ADORA3 (0.40) KDM4EADORA3TP53ADORA1ADORA2A
SCHEMBL23921232 0.68 ADORA3 (0.37) KDM4EMAPTMEN1KMT2ARAB9A
SCHEMBL23921008 0.68 ADORA3 (0.42) KDM4EADORA3TP53ADORA1ADORA2A
SCHEMBL23921120 0.67 ADORA3 (0.41) ADORA3TP53ADORA1ADORA2AADORA2B
SCHEMBL23921157 0.67 TDP1 (0.41) ADORA3TP53ADORA1ADORA2AADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230242568-A1 POLYMER LINKED MULTIMERS OF GUANOSINE-3', 5'-CYCLIC MONOPHOSPHATES MIRECA MEDICINES GMBH (DE) 2023-08-03 US disclosed
US-20210317156-A1 NEW POLYMER LINKED MULTIMERS OF GUANOSINE-3', 5'-CYCLIC MONOPHOSPHATES MIRECA MEDICINES GMBH (DE) 2021-10-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230242568-A1 POLYMER LINKED MULTIMERS OF GUANOSINE-3', 5'-CYCLIC MONOPHOSPHATES PRKG1, PRKG2, PRKAG3 KDM4E 598/4885MAPT 4120/4885MEN1 2620/4885
US-20210317156-A1 NEW POLYMER LINKED MULTIMERS OF GUANOSINE-3', 5'-CYCLIC MONOPHOSPHATES PRKG1, PRKG2, PDE7A KDM4E 638/4885MAPT 4036/4885MEN1 2840/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.