Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 3/20 | 0.49 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.42 |
| ▸ | PRMT8 | Q9NR22 | 2/20 | 0.42 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7745202 | 0.93 | CACNA1H (0.45) | CACNA1HCARM1PRMT6PRMT8ACE2 | |
| SCHEMBL10245377 | 0.91 | CACNA1H (0.44) | CACNA1HCARM1PRMT6PRMT8ACE2 | |
| SCHEMBL10192177 | 0.90 | CARM1 (0.56) | CACNA1HCARM1PRMT6PRMT8SMN1; SMN2 | |
| SCHEMBL19961023 | 0.90 | CARM1 (0.50) | CACNA1HCARM1PRMT6PRMT8ACE2 | |
| SCHEMBL18591749 | 0.89 | CACNA1H (0.47) | CACNA1HCARM1PRMT6PRMT8ACE2 | |
| SCHEMBL12262499 | 0.89 | CACNA1H (0.43) | CACNA1HCARM1PRMT6PRMT8ACE2 | |
| SCHEMBL7745180 | 0.88 | CARM1 (0.54) | CACNA1HCARM1PRMT6PRMT8SMN1; SMN2 | |
| SCHEMBL13137785 | 0.88 | CARM1 (0.54) | CACNA1HCARM1PRMT6PRMT8SMN1; SMN2 | |
| SCHEMBL18611449 | 0.87 | CACNA1H (0.42) | CACNA1HACE2SMN1; SMN2DRD2 | |
| SCHEMBL20317549 | 0.85 | CACNA1H (0.41) | CACNA1HCARM1PRMT6PRMT8ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11147884-B2 | Inhibitors of NHE-mediated antiport | ARDELYX, INC. (US) | 2021-10-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11147884-B2 | Inhibitors of NHE-mediated antiport | SLC10A1, SLC10A2, SLC9A2 | CACNA1H 1762/4885CARM1 3841/4885PRMT6 3934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.