Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19898592 | 0.90 | SMYD2 (0.34) | SMYD2RIPK1 | |
| SCHEMBL1462582 | 0.90 | SMYD2 (0.34) | SMYD2RIPK1 | |
| SCHEMBL20484877 | 0.90 | SMYD2 (0.34) | SMYD2RIPK1 | |
| SCHEMBL1439229 | 0.82 | ABCB1 (0.39) | HCRTR2 | |
| SCHEMBL1439534 | 0.82 | ABCB1 (0.39) | HCRTR2 | |
| SCHEMBL21987604 | 0.81 | SMYD2 (0.35) | SMYD2RIPK1 | |
| SCHEMBL25368638 | 0.80 | FKBP1A (0.36) | — | |
| SCHEMBL1439385 | 0.79 | SMYD2 (0.35) | SMYD2 | |
| SCHEMBL21987485 | 0.79 | SMYD2 (0.35) | SMYD2RIPK1 | |
| SCHEMBL2146189 | 0.79 | RIPK1 (0.42) | SMYD2RIPK1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012980-B2 | Isoquinolinone derivatives | ASTRAZENECA AB (SE) | 2011-09-06 | — | — | US | disclosed |
| US-20100099665-A1 | ISOQUINOLINONE DERIVATIVES | ASTRAZENECA AB (SE) | 2010-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100099665-A1 | ISOQUINOLINONE DERIVATIVES | SDHA, NQO1, CYP3A5 | SMYD2 4708/4885RIPK1 4375/4885HCRTR2 3013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.