Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 6/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14845181 | 0.74 | KDM4E (0.55) | HPGDKDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL8627262 | 0.73 | ALDH1A1 (0.54) | HPGDKDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL15999546 | 0.73 | KDM4E (0.54) | HPGDKDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL11512750 | 0.72 | KDM4E (0.48) | HPGDKDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL11576271 | 0.71 | KDM4E (0.52) | HPGDKDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL8625170 | 0.71 | KDM4E (0.52) | HPGDKDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL11512749 | 0.70 | KDM4E (0.51) | HPGDKDM4EALDH1A1HSD17B10TSHR | |
| Tioxacin SCHEMBL2109483 | 0.69 | KDM4E (0.50) | HPGDKDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL7057692 | 0.69 | KDM4E (0.70) | HPGDKDM4EALDH1A1HSD17B10TSHR | |
| SCHEMBL11404246 | 0.68 | KDM4E (0.51) | HPGDKDM4EALDH1A1HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115461056-B | Inhibitors of Lebaba-specific tyrosine phosphatase (LYP) | 普渡研究基金会 | 2024-04-16 | — | — | CN | disclosed |
| US-11629130-B2 | Lymphoid-specific tyrosine phosphatase (LYP) inhibitors | PURDUE RESEARCH FOUNDATION (US) | 2023-04-18 | — | — | US | disclosed |
| EP-4135711-A1 | NOVEL LYMPHOID-SPECIFIC TYROSINE PHOSPHATASE (LYP) INHIBITORS | Purdue Research Foundation (US) | 2023-02-22 | — | — | EP | disclosed |
| CN-115461056-A | Novel lymphoid specific tyrosine phosphatase (LYP) inhibitors | 普渡研究基金会 | 2022-12-09 | — | — | CN | disclosed |
| WO-2021211191-A1 | NOVEL LYMPHOID-SPECIFIC TYROSINE PHOSPHATASE (LYP) INHIBITORS | PURDUE RESEARCH FOUNDATION (US) | 2021-10-21 | — | — | WO | disclosed |
| US-20210323926-A1 | Novel Lymphoid-Specific Tyrosine Phosphatase (LYP) Inhibitors | PURDUE RESEARCH FOUNDATION (US) | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11629130-B2 | Lymphoid-specific tyrosine phosphatase (LYP) inhibitors | PTPN22, PTPN1, PTPRCAP | HPGD 4245/4885KDM4E 578/4885ALDH1A1 2774/4885 |
| US-20210323926-A1 | Novel Lymphoid-Specific Tyrosine Phosphatase (LYP) Inhibitors | PTPN22, PTPN1, PTPRCAP | HPGD 4158/4885KDM4E 533/4885ALDH1A1 2786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.