SCHEMBL22323337

SCHEMBL22323337

CC[Si](C#Cc1cnc(O[C@@H]2C[C@H](C)N(C(=O)O)C2)cn1)(CC)CC

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 1/20 0.33
PIK3CD O00329 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29496515 0.87 GPR119 (0.44) GPR119PIK3CD
SCHEMBL21807918 0.80 HCRTR1 (0.34) GPR119PIK3CD
SCHEMBL22323300 0.76 HCRTR1 (0.34) GPR119PIK3CD
SCHEMBL22323290 0.73
SCHEMBL22337993 0.73 GPR119 (0.44) GPR119PIK3CD
SCHEMBL23924451 0.72 GPR119 (0.53) GPR119
SCHEMBL21807912 0.71 OGA (0.38)
SCHEMBL21807893 0.71 DGAT1 (0.42)
SCHEMBL21807905 0.70 ALDH1A1 (0.36)
SCHEMBL22323316 0.67 ACACB (0.32) PIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3921316-A1 BICYCLIC ETHER O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITORS Biogen MA Inc. (US) 2021-12-15 EP disclosed
WO-2020163193-A1 BICYCLIC ETHER O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITORS BIOGEN MA INC. (US) 2020-08-13 WO disclosed