Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1144143 | 0.86 | MCHR1 (0.44) | TSHRSMN1; SMN2GLAKDM4EPTGDR2 | |
| SCHEMBL6357684 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2KDM4ETDP1LMNAL3MBTL1 | |
| SCHEMBL4816613 | 0.77 | SMN1; SMN2 (0.42) | TSHRSMN1; SMN2GLAKDM4EPTGDR2 | |
| SCHEMBL23925230 | 0.77 | FDPS (0.41) | SMN1; SMN2KDM4EPTGDR2TDP1MAPT | |
| SCHEMBL4572874 | 0.77 | KDM4E (0.59) | TSHRSMN1; SMN2GLAKDM4ETDP1 | |
| SCHEMBL16637913 | 0.74 | ALDH1A1 (0.45) | KDM4ETDP1MAPTMAPK1 | |
| SCHEMBL13010769 | 0.74 | HPGD (0.55) | TSHRSMN1; SMN2GLAKDM4ETDP1 | |
| SCHEMBL3119610 | 0.72 | MAPT (0.50) | SMN1; SMN2KDM4ETDP1GAAMAPT | |
| SCHEMBL12264984 | 0.72 | SMN1; SMN2 (0.49) | SMN1; SMN2TDP1MAPTLMNAL3MBTL1 | |
| Methyl Alcohol SCHEMBL28799088 | 0.72 | CA2 (0.52) | TSHRSMN1; SMN2KDM4ETDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4136084-A1 | BCL-2 INHIBITOR | BeiGene, Ltd. (KY) | 2023-02-22 | — | — | EP | disclosed |
| WO-2021208963-A1 | BCL-2 INHIBITOR | BEIGENE, LTD. (KY) | 2021-10-21 | — | — | WO | disclosed |