Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15911113 | 0.77 | PDE4D (0.51) | PDE4DLMNAL3MBTL1CYP2C19DYRK1A | |
| SCHEMBL30090296 | 0.76 | PDE4D (0.50) | PDE4DLMNAL3MBTL1CYP2C19KDM4E | |
| SCHEMBL5700603 | 0.76 | PDE4D (0.50) | PDE4DLMNAL3MBTL1CYP2C19KDM4E | |
| SCHEMBL1640767 | 0.76 | PDE4D (0.59) | PDE4DLMNAL3MBTL1CYP2C19DYRK1A | |
| SCHEMBL1663754 | 0.76 | PDE4D (0.59) | PDE4DLMNAL3MBTL1CYP2C19DYRK1A | |
| SCHEMBL23926008 | 0.74 | PDE4D (0.57) | PDE4DLMNAL3MBTL1CYP2C19DYRK1A | |
| SCHEMBL15777023 | 0.74 | PDE4D (0.57) | PDE4DLMNAL3MBTL1CYP2C19DYRK1A | |
| SCHEMBL4631791 | 0.73 | AURKA (0.51) | LMNAL3MBTL1GAAMEN1KMT2A | |
| SCHEMBL9125632 | 0.73 | CSNK2A2 (0.56) | PDE4DLMNAL3MBTL1CYP2C19KDM4E | |
| SCHEMBL24131083 | 0.72 | TAS1R3 (0.53) | LMNAL3MBTL1CYP2C19GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4341247-A1 | RIP1 MODULATORS INCLUDING AZETIDINE CYCLIC UREAS, PREPARATIONS, AND USES THEREOF | Sironax Ltd (KY) | 2024-03-27 | — | — | EP | disclosed |
| CN-117355506-A | RIP1 modulators comprising azetidine cyclic ureas, preparation and use thereof | 维泰瑞隆有限公司 | 2024-01-05 | — | — | CN | disclosed |
| WO-2022242581-A1 | RIP1 MODULATORS INCLUDING AZETIDINE CYCLIC UREAS, PREPARATIONS, AND USES THEREOF | Sironax Ltd. (KY) | 2022-11-24 | — | — | WO | disclosed |
| US-8148380-B2 | Antibacterial amide and sulfonamide substituted heterocyclic urea compounds | CRESTONE, INC. (US) | 2012-04-03 | — | — | US | disclosed |
| US-20120015941-A1 | Antibacterial Amide and Sulfonamide Substituted Heterocyclic Urea Compounds | CRESTONE, INC. (US) | 2012-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120015941-A1 | Antibacterial Amide and Sulfonamide Substituted Heterocyclic Urea Compounds | NAAA, AADAC, RPSA | PDE4D 1640/4885LMNA 4293/4885L3MBTL1 4619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.