Sugi Predict

Sugi Predict / Compounds / SCHEMBL23926508

SCHEMBL23926508

SCHEMBL23926508

CN(C)C(=O)c1cc2cc([N+](=O)[O-])cnc2[nH]1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 2/20 0.42
▸ HTT P42858 1/20 0.42
▸ FGFR1 P11362 1/20 0.41
▸ FGFR2 P21802 1/20 0.41
▸ MAP4K1 Q92918 1/20 0.40
▸ L3MBTL1 Q9Y468 1/20 0.40
▸ ALDH1A1 P00352 3/20 0.39
▸ CDK2 P24941 2/20 0.39
▸ MEN1 O00255 1/20 0.38
▸ HPGD P15428 1/20 0.38
▸ NPSR1 Q6W5P4 1/20 0.38
▸ CYP1A2 P05177 1/20 0.37
▸ GAA P10253 1/20 0.37
▸ LMNA P02545 1/20 0.36
▸ CCNK O75909 1/20 0.36
▸ CDK12 Q9NYV4 1/20 0.36
▸ NUDT1 P36639 1/20 0.36
▸ CYP2C19 P33261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1773116 0.85 CYP1A2 (0.42) ALDH1A1CYP1A2GAACYP2C19
SCHEMBL13261081 0.84 MAPK1 (0.37) KMT2AHTTALDH1A1HPGDCYP1A2
SCHEMBL16592715 0.83 APEX1 (0.44) KMT2AALDH1A1MEN1HPGDCYP1A2
SCHEMBL12393061 0.83 APEX1 (0.44) KMT2AALDH1A1MEN1HPGDCYP1A2
SCHEMBL15859814 0.82 ALDH1A1 (0.40) FGFR1FGFR2ALDH1A1CYP1A2GAA
SCHEMBL12393058 0.82 ABL1 (0.48) —
SCHEMBL18403156 0.82 ALDH1A1 (0.42) KMT2AL3MBTL1ALDH1A1MEN1CYP1A2
SCHEMBL13260628 0.82 ALDH1A1 (0.42) KMT2AALDH1A1CYP1A2GAALMNA
SCHEMBL16536680 0.77 FGFR1 (0.44) HTTFGFR1FGFR2MAP4K1CDK2
SCHEMBL23974728 0.75 ALDH1A1 (0.46) KMT2AHTTALDH1A1MEN1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12590071-B2 Hydrazone derivative in which terminal amine group is substituted with aryl group or heteroaryl group, and use thereof KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2026-03-31 — — US disclosed
CN-113727972-B Novel hydrazone derivatives having terminal amine groups substituted with aryl or heteroaryl groups and use thereof 韩国科学技术研究院 2024-12-27 — — CN disclosed
US-20220396553-A1 NOVEL HYDRAZONE DERIVATIVE IN WHICH TERMINAL AMINE GROUP IS SUBSTITUTED WITH ARYL GROUP OR HETEROARYL GROUP, AND USE THEREOF KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 2022-12-15 — — US disclosed
EP-3901139-A1 NOVEL HYDRAZONE DERIVATIVE WITH ARYL OR HETEROARYL GROUP SUBSTITUTED AT TERMINAL AMINE GROUP THEREOF AND USE THEREOF Korea Institute of Science and Technology (KR) 2021-10-27 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12590071-B2 Hydrazone derivative in which terminal amine group is substituted with aryl group or heteroaryl group, and use thereof ABL1, TH, CYP3A43 KMT2A 1604/4885HTT 531/4885FGFR1 802/4885
US-20220396553-A1 NOVEL HYDRAZONE DERIVATIVE IN WHICH TERMINAL AMINE GROUP IS SUBSTITUTED WITH ARYL GROUP OR HETEROARYL GROUP, AND USE THEREOF AANAT, NAT1, HNMT KMT2A 342/4885HTT 116/4885FGFR1 3284/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.