Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2389761 | 0.72 | CYP3A4 (0.41) | LMNAALDH1A1CYP3A4HSD17B10GLA | |
| SCHEMBL2391023 | 0.72 | CYP3A4 (0.41) | LMNAALDH1A1CYP3A4HSD17B10GLA | |
| SCHEMBL1643462 | 0.71 | OPRM1 (0.39) | — | |
| SCHEMBL2390992 | 0.66 | KDM4E (0.37) | ALDH1A1MEN1KMT2A | |
| SCHEMBL11748306 | 0.66 | IDO1 (0.38) | LMNAALDH1A1CYP3A4HSD17B10GLA | |
| SCHEMBL1841591 | 0.65 | LMNA (0.46) | LMNAALDH1A1CYP3A4GLAHPGD | |
| SCHEMBL11744544 | 0.65 | GAA (0.41) | ALDH1A1CYP3A4HSD17B10GLAHPGD | |
| SCHEMBL1190993 | 0.64 | CYP3A4 (0.39) | LMNAALDH1A1CYP3A4HSD17B10HTR2C | |
| SCHEMBL28856820 | 0.64 | ABCB1 (0.48) | LMNAALDH1A1HPGD | |
| SCHEMBL1642227 | 0.64 | ALDH1A1 (0.39) | ALDH1A1GLAHPGDHTR2CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8013008-B2 | Cyclic amine compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-09-06 | — | — | US | disclosed |