Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 10/20 | 0.49 |
| ▸ | NPC1 | O15118 | 9/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.49 |
| ▸ | RELA | Q04206 | 2/20 | 0.49 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.43 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2391009 | 0.99 | HDAC1 (0.48) | HDAC1HDAC6RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL12307070 | 0.87 | HDAC1 (0.48) | HDAC1HDAC6RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL27016029 | 0.87 | HDAC1 (0.48) | HDAC1HDAC6RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL12256182 | 0.87 | HDAC1 (0.48) | HDAC1HDAC6RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20833644 | 0.87 | HDAC1 (0.48) | HDAC1HDAC6RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL12256155 | 0.87 | HDAC6 (0.40) | HDAC1HDAC6RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2391593 | 0.86 | NPC1 (0.50) | HDAC1HDAC6RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL20833643 | 0.85 | NPC1 (0.49) | HDAC1HDAC6RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL27015692 | 0.85 | HDAC1 (0.46) | HDAC1HDAC6RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2388881 | 0.85 | NPC1 (0.49) | HDAC1HDAC6RAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108368006-B | DNA binding agents with minor groove binding tails | 得克萨斯州大学系统董事会 | 2023-03-07 | — | — | CN | disclosed |
| EP-3350145-B1 | DNA BINDING AGENTS WITH A MINOR GROOVE BINDING TAIL | UNIV TEXAS (US) | 2020-09-16 | — | — | EP | disclosed |
| EP-3350145-B1 | DNA BINDING AGENTS WITH A MINOR GROOVE BINDING TAIL | UNIV TEXAS (US) | 2020-09-16 | — | — | EP | disclosed |
| US-10358439-B2 | DNA binding agents with a minor groove binding tail | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-07-23 | — | — | US | disclosed |
| US-10358439-B2 | DNA binding agents with a minor groove binding tail | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2019-07-23 | — | — | US | disclosed |
| US-20180251454-A1 | DNA BINDING AGENTS WITH A MINOR GROOVE BINDING TAIL | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2018-09-06 | — | — | US | disclosed |
| EP-3350145-A1 | DNA BINDING AGENTS WITH A MINOR GROOVE BINDING TAIL | Board of Regents, The University of Texas System (US) | 2018-07-25 | — | — | EP | disclosed |
| WO-2017049091-A1 | DNA BINDING AGENTS WITH A MINOR GROOVE BINDING TAIL | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-03-23 | — | — | WO | disclosed |
| WO-2017049091-A1 | DNA BINDING AGENTS WITH A MINOR GROOVE BINDING TAIL | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-03-23 | — | — | WO | disclosed |
| US-8017599-B2 | Sequence selective pyrrole and imidazole polyamide metallocomplexes | UNIVERSITY OF WESTERN SYDNEY (AU) | 2011-09-13 | — | — | US | disclosed |
| US-8017599-B2 | Sequence selective pyrrole and imidazole polyamide metallocomplexes | UNIVERSITY OF WESTERN SYDNEY (AU) | 2011-09-13 | — | — | US | disclosed |
| EP-1678133-A4 | SEQUENCE SELECTIVE PYRROLE AND IMIDAZOLE POLYAMIDE METALLOCOMPLEXES | UNIV WESTERN SYDNEY (AU) | 2008-06-18 | — | — | EP | disclosed |
| US-20070265240-A1 | Sequence Selective Pyrrole and Imidazole Polyamide Metallocomplexes | UNIVERSITY OF WESTERN SYDNEY (AU) | 2007-11-15 | — | — | US | disclosed |
| EP-1678133-A1 | SEQUENCE SELECTIVE PYRROLE AND IMIDAZOLE POLYAMIDE METALLOCOMPLEXES | University of Western Sydney (AU) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005033077-A1 | SEQUENCE SELECTIVE PYRROLE AND IMIDAZOLE POLYAMIDE METALLOCOMPLEXES | UNIVERSITY OF WESTERN SYDNEY (AU) | 2005-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10358439-B2 | DNA binding agents with a minor groove binding tail | TOP2B, TOP2A, TOP1 | HDAC1 607/4885HDAC6 1112/4885RAB9A 2785/4885 |
| US-20070265240-A1 | Sequence Selective Pyrrole and Imidazole Polyamide Metallocomplexes | POLRMT, MPI, PPIF | HDAC1 2739/4885HDAC6 823/4885RAB9A 4050/4885 |
| US-20180251454-A1 | DNA BINDING AGENTS WITH A MINOR GROOVE BINDING TAIL | TOP2B, TOP2A, TOP1 | HDAC1 607/4885HDAC6 1112/4885RAB9A 2785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.