Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.70 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 5/20 | 0.44 |
| ▸ | HTR6 | P50406 | 4/20 | 0.41 |
| ▸ | FABP4 | P15090 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23927920 | 1.00 | HTR2C (0.70) | HTR2CPRMT5HTR2AHTR6FABP4 | |
| SCHEMBL23956112 | 0.82 | HTR2C (0.47) | HTR2CPRMT5HTR2AHTR6KDM4E | |
| SCHEMBL23927925 | 0.82 | HTR2C (0.47) | HTR2CPRMT5HTR2AKDM4EALDH1A1 | |
| SCHEMBL23927923 | 0.82 | HTR2C (0.47) | HTR2CPRMT5HTR2AKDM4EALDH1A1 | |
| SCHEMBL25790949 | 0.81 | HTR2C (0.47) | HTR2CPRMT5HTR2AKDM4E | |
| SCHEMBL23956087 | 0.81 | HTR2C (0.46) | HTR2CPRMT5HTR2A | |
| SCHEMBL23927854 | 0.77 | HTR2C (0.42) | HTR2CHTR2AHTR6FABP4ALDH1A1 | |
| SCHEMBL23927852 | 0.77 | HTR2C (0.42) | HTR2CHTR2AHTR6FABP4ALDH1A1 | |
| SCHEMBL29780344 | 0.77 | HTR2C (0.42) | HTR2CHTR2AHTR6FABP4ALDH1A1 | |
| SCHEMBL13228252 | 0.77 | HTR2C (0.65) | HTR2CPRMT5HTR6FABP4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220251040-A1 | N-SUBSTITUTED INDOLES AND OTHER HETEROCYCLES FOR TREATING BRAIN DISORDERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2022-08-11 | — | — | US | disclosed |
| US-11254640-B2 | N-substituted indoles and other heterocycles for treating brain disorders | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2022-02-22 | — | — | US | disclosed |
| US-20210332012-A1 | N-SUBSTITUTED INDOLES AND OTHER HETEROCYCLES FOR TREATING BRAIN DISORDERS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA CORPORATION | 2021-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11254640-B2 | N-substituted indoles and other heterocycles for treating brain disorders | TPH2, AANAT, HTR2C | HTR2C 3/4885PRMT5 796/4885HTR2A 5/4885 |
| US-20220251040-A1 | N-SUBSTITUTED INDOLES AND OTHER HETEROCYCLES FOR TREATING BRAIN DISORDERS | TPH2, AANAT, HTR2C | HTR2C 3/4885PRMT5 796/4885HTR2A 5/4885 |
| US-20210332012-A1 | N-SUBSTITUTED INDOLES AND OTHER HETEROCYCLES FOR TREATING BRAIN DISORDERS | TPH2, AANAT, HTR2C | HTR2C 3/4885PRMT5 796/4885HTR2A 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.