Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 11/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 8/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | USP2 | O75604 | 8/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | HPGDS | O60760 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23928581 | 0.82 | GAA (0.58) | GAACYP1A2SMN1; SMN2CYP2D6CYP2C9 | |
| SCHEMBL23928626 | 0.80 | GAA (0.56) | GAACYP1A2SMN1; SMN2CYP2D6CYP2C9 | |
| SCHEMBL23928499 | 0.77 | NPSR1 (0.62) | GAACYP1A2SMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL22111256 | 0.76 | NPSR1 (0.64) | GAACYP1A2SMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL23928650 | 0.76 | GAA (0.52) | GAACYP1A2SMN1; SMN2CYP2D6CYP3A4 | |
| SCHEMBL5658689 | 0.74 | USP2 (0.78) | GAACYP1A2SMN1; SMN2CYP2D6CYP2C9 | |
| SCHEMBL28735924 | 0.71 | MAPT (0.58) | SMN1; SMN2MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL23928645 | 0.70 | GAA (0.55) | GAACYP1A2SMN1; SMN2CYP2D6CYP2C9 | |
| SCHEMBL23104631 | 0.70 | CDK1 (0.43) | MAPK1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL23928553 | 0.70 | GAA (0.57) | GAACYP1A2SMN1; SMN2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11548875-B2 | Inhibitor compounds for male contraception | UNIVERSITY OF WASHINGTON (US) | 2023-01-10 | — | — | US | disclosed |
| US-20210332030-A1 | INHIBITOR COMPOUNDS FOR MALE CONTRACEPTION | UNIVERSITY OF WASHINGTON (US) | 2021-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210332030-A1 | INHIBITOR COMPOUNDS FOR MALE CONTRACEPTION | ALDH1A1, ALDH3A1, ALDH16A1 | GAA 3740/4885CYP1A2 17/4885SMN1; SMN2 2873/4885 |
| US-11548875-B2 | Inhibitor compounds for male contraception | ALDH1A1, ALDH3A1, ALDH16A1 | GAA 3740/4885CYP1A2 17/4885SMN1; SMN2 2873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.