Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 9/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.78 |
| ▸ | MEN1 | O00255 | 4/20 | 0.78 |
| ▸ | HPGD | P15428 | 3/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.78 |
| ▸ | TP53 | P04637 | 2/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.67 |
| ▸ | TSHR | P16473 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | HPGDS | O60760 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30125105 | 0.85 | CYP1A2 (0.58) | USP2CYP1A2CYP3A4KMT2AMEN1 | |
| SCHEMBL30124750 | 0.85 | CYP1A2 (0.58) | USP2CYP1A2CYP3A4KMT2AMEN1 | |
| SCHEMBL30124856 | 0.84 | USP2 (0.59) | USP2CYP1A2CYP3A4KMT2AMEN1 | |
| SCHEMBL5655889 | 0.82 | KMT2A (0.63) | USP2CYP1A2CYP3A4KMT2AMEN1 | |
| SCHEMBL14590544 | 0.81 | KMT2A (0.57) | USP2CYP1A2CYP3A4KMT2AMEN1 | |
| SCHEMBL5655224 | 0.80 | ALDH1A1 (0.69) | USP2CYP1A2CYP3A4KMT2AMEN1 | |
| SCHEMBL3763788 | 0.79 | MAOB (0.64) | USP2CYP1A2CYP3A4KMT2AMEN1 | |
| SCHEMBL23928581 | 0.78 | GAA (0.58) | USP2CYP1A2CYP3A4KMT2AMEN1 | |
| SCHEMBL23000070 | 0.78 | HPGDS (0.81) | USP2CYP1A2CYP3A4KMT2AMEN1 | |
| SCHEMBL23928553 | 0.77 | GAA (0.57) | USP2CYP1A2CYP3A4KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7229991-B2 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxamides | GRUENENTHAL GMBH (DE) | 2007-06-12 | — | — | US | disclosed |
| US-20050288342-A1 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxamides | GRUENENTHAL GMBH (DE) | 2005-12-29 | — | — | US | disclosed |
| EP-1581490-A1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROLE-2-CARBOXAMIDES | Grünenthal GmbH (DE) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004058707-A1 | SUBSTITUTED 5-AMINOMETHYL-1H-PYRROLE-2-CARBOXAMIDES | Grünenthal GmbH (DE) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288342-A1 | Substituted 5-aminomethyl-1H-pyrrole-2-carboxamides | QPCT, PGA5, ALDH18A1 | USP2 3015/4885CYP1A2 129/4885CYP3A4 310/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.