Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3076892 | 0.77 | MAPT (0.50) | MAPTKMT2AHSP90AA1GPR55TSHR | |
| SCHEMBL6642017 | 0.73 | MAPT (0.55) | MAPTKMT2AKCNN4NAPRTHSD17B10 | |
| SCHEMBL9756879 | 0.72 | MAPT (0.59) | MAPTHSP90AA1GPR55KCNN4TSHR | |
| SCHEMBL28531503 | 0.72 | MAPT (0.59) | MAPTHSP90AA1GPR55KCNN4TSHR | |
| SCHEMBL5586031 | 0.71 | PDK1 (0.45) | MAPTKMT2AHSP90AA1GPR55KCNN4 | |
| SCHEMBL21467646 | 0.71 | MAPT (0.46) | MAPTHSP90AA1GPR55KCNN4TSHR | |
| SCHEMBL28229440 | 0.70 | MAPT (0.57) | MAPTHSP90AA1GPR55KCNN4TSHR | |
| SCHEMBL1339748 | 0.69 | NAPRT (0.43) | MAPTKMT2AHSP90AA1GPR55TSHR | |
| SCHEMBL11258986 | 0.69 | MAPT (0.41) | MAPTKMT2ATSHRNAPRTHSD17B10 | |
| SCHEMBL11674465 | 0.69 | CYP2D6 (0.43) | MAPTKMT2ANAPRTHSD17B10RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4139286-A1 | SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION | Bayer Aktiengesellschaft (DE) | 2023-03-01 | — | — | EP | claimed |
| WO-2021214019-A1 | SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION | BAYER AKTIENGESELLSCHAFT (DE) | 2021-10-28 | — | — | WO | claimed |