Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 8/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.49 |
| ▸ | FAP | Q12884 | 4/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.49 |
| ▸ | PREP | P48147 | 3/20 | 0.49 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.49 |
| ▸ | PITRM1 | Q5JRX3 | 1/20 | 0.49 |
| ▸ | REN | P00797 | 3/20 | 0.45 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PEPD | P12955 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3817115 | 0.82 | DPP4 (0.41) | DPP4DPP7FAPDPP8DPP9 | |
| SCHEMBL24648933 | 0.82 | DPP4 (0.51) | DPP4DPP7FAPDPP8PREP | |
| SCHEMBL5994759 | 0.81 | DPP4 (0.56) | DPP4DPP7FAPDPP8PREP | |
| SCHEMBL24441097 | 0.81 | DPP4 (0.56) | DPP4DPP7FAPDPP8PREP | |
| SCHEMBL2393013 | 0.80 | DPP4 (0.49) | DPP4DPP7FAPDPP8PREP | |
| SCHEMBL24648734 | 0.78 | DPP4 (0.50) | DPP4DPP7FAPDPP8PREP | |
| SCHEMBL29692517 | 0.78 | DPP4 (0.50) | DPP4DPP7FAPDPP8PREP | |
| SCHEMBL13340679 | 0.77 | DPP4 (0.49) | DPP4DPP7FAPDPP8PREP | |
| SCHEMBL13338977 | 0.77 | DPP4 (0.49) | DPP4DPP7FAPDPP8PREP | |
| SCHEMBL7311191 | 0.77 | DPP4 (0.49) | DPP4DPP7FAPDPP8PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086993-B1 | MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS | ZEDIRA GMBH (DE) | 2015-03-11 | — | — | EP | disclosed |
| US-8471063-B2 | Michael systems as transglutaminase inhibitors | ZEDIRA GMBH (DE) | 2013-06-25 | — | — | US | disclosed |
| US-20110229568-A1 | MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS | ZEDIRA GMBH (DE) | 2011-09-22 | — | — | US | disclosed |
| EP-2086993-A1 | MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS | Zedira GmbH (DE) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008055488-A1 | MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS | ZEDIRA GMBH (DE) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110229568-A1 | MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS | TGM2, TGM3, TGM1 | DPP4 248/4885DPP7 180/4885FAP 147/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.