Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.41 |
| ▸ | REN | P00797 | 3/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.41 |
| ▸ | FAP | Q12884 | 2/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 3/20 | 0.41 |
| ▸ | STAT3 | P40763 | 5/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2408415 | 0.84 | OPRM1 (0.48) | DPP4RENDPP8DPP9DPP7 | |
| SCHEMBL2393010 | 0.82 | DPP4 (0.49) | DPP4RENDPP8DPP9DPP7 | |
| SCHEMBL4337493 | 0.80 | DPP4 (0.45) | DPP4RENDPP8DPP9DPP7 | |
| SCHEMBL4337499 | 0.80 | DPP4 (0.45) | DPP4RENDPP8DPP9DPP7 | |
| SCHEMBL3813773 | 0.78 | PEPD (0.57) | DPP4RENDPP8DPP9DPP7 | |
| SCHEMBL23781697 | 0.78 | DPP4 (0.49) | DPP4RENDPP8DPP9DPP7 | |
| SCHEMBL24011941 | 0.78 | DPP4 (0.49) | DPP4RENDPP8DPP9DPP7 | |
| SCHEMBL23781698 | 0.78 | DPP4 (0.49) | DPP4RENDPP8DPP9DPP7 | |
| SCHEMBL5970696 | 0.78 | ACE (0.57) | DPP4RENDPP8DPP9DPP7 | |
| SCHEMBL5970700 | 0.78 | ACE (0.57) | DPP4RENDPP8DPP9DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2086993-A1 | MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS | Zedira GmbH (DE) | 2009-08-12 | — | — | EP | claimed |
| WO-2008055488-A1 | MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS | ZEDIRA GMBH (DE) | 2008-05-15 | — | — | WO | claimed |
| EP-2086993-A1 | MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS | Zedira GmbH (DE) | 2009-08-12 | — | — | EP | disclosed |
| WO-2008055488-A1 | MICHAEL SYSTEMS AS TRANSGLUTAMINASE INHIBITORS | ZEDIRA GMBH (DE) | 2008-05-15 | — | — | WO | disclosed |