Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | VNN1 | O95497 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23930730 | 1.00 | PIK3CD (0.51) | PIK3CDHSP90AA1ALDH1A1MAPTPKM | |
| SCHEMBL30194846 | 0.91 | PIK3CD (0.50) | PIK3CDHSP90AA1ALDH1A1MAPTPKM | |
| SCHEMBL23959381 | 0.80 | ALDH1A1 (0.47) | PIK3CDHSP90AA1ALDH1A1MAPTPKM | |
| SCHEMBL28478515 | 0.78 | ALDH1A1 (0.45) | PIK3CDHSP90AA1ALDH1A1MAPTPKM | |
| SCHEMBL23959527 | 0.77 | PIK3CD (0.47) | PIK3CDHSP90AA1ALDH1A1MAPTPKM | |
| SCHEMBL11100629 | 0.77 | GAA (0.51) | PIK3CDHSP90AA1ALDH1A1MAPTPKM | |
| SCHEMBL31738591 | 0.76 | PIK3CD (0.48) | PIK3CDHSP90AA1ALDH1A1MAPTPKM | |
| SCHEMBL14887797 | 0.76 | ALDH1A1 (0.53) | PIK3CDHSP90AA1ALDH1A1MAPTPKM | |
| SCHEMBL31428487 | 0.74 | HPGD (0.59) | PIK3CDHSP90AA1ALDH1A1MAPTPKM | |
| SCHEMBL27888737 | 0.74 | SMN1; SMN2 (0.66) | ALDH1A1MAPTGAANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4139295-B1 | ISOQUINILINE NRF2 AGONISTS | C4X DISCOVERY LTD (GB) | 2025-04-09 | — | — | EP | disclosed |
| CN-115667242-B | Tetrahydroisoquinoline compounds as NRF2 activators | 希四克斯探索有限公司 | 2025-02-28 | — | — | CN | disclosed |
| US-20230159511-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS NRF2 ACTIVATORS | C4X DISCOVERY LIMITED (GB) | 2023-05-25 | — | — | US | disclosed |
| EP-4139295-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS NRF2 ACTIVATORS | C4x Discovery Limited (GB) | 2023-03-01 | — | — | EP | disclosed |
| CN-115667242-A | Tetrahydroisoquinoline compounds as NRF2 activators | 希四克斯探索有限公司 | 2023-01-31 | — | — | CN | disclosed |
| WO-2021214472-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS NRF2 ACTIVATORS | C4X DISCOVERY LIMITED (GB) | 2021-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159511-A1 | TETRAHYDROISOQUINOLINE COMPOUNDS AS NRF2 ACTIVATORS | NFE2L2, KEAP1, NQO1 | PIK3CD 2624/4885HSP90AA1 1319/4885ALDH1A1 773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.