Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | CTSE | P14091 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.43 |
| ▸ | STS | P08842 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | EED | O75530 | 1/20 | 0.42 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.42 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24126466 | 0.93 | SRC (0.44) | HCAR1GPR119ALDH1A1POLBCTSD | |
| SCHEMBL23960115 | 0.93 | SRC (0.44) | HCAR1GPR119ALDH1A1POLBCTSD | |
| SCHEMBL21879883 | 0.88 | POLB (0.40) | HCAR1GPR119POLB | |
| SCHEMBL21880090 | 0.88 | ALDH1A1 (0.48) | HCAR1GPR119ALDH1A1POLBMAPT | |
| SCHEMBL21879888 | 0.82 | SRC (0.48) | HCAR1GPR119POLB | |
| SCHEMBL21879911 | 0.82 | SRC (0.48) | HCAR1GPR119POLB | |
| SCHEMBL21879885 | 0.82 | SRC (0.48) | HCAR1GPR119POLB | |
| SCHEMBL23930836 | 0.79 | GPR119 (0.35) | HCAR1GPR119ALDH1A1POLBSTS | |
| SCHEMBL10137696 | 0.76 | CCNA2 (0.50) | HCAR1GPR119POLBNR3C1 | |
| SCHEMBL948610 | 0.76 | HCAR1 (0.54) | HCAR1GPR119CTSDCTSEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021215545-A1 | ANTICANCER COMBINATION THERAPY WITH N-(1-ACRYLOYL-AZETIDIN-3-YL)-2-((1H-INDAZOL-3-YL)AMINO)METHYL)-1H-IMIDAZOLE-5-CARBOXAMIDE INHIBITOR OF KRAS-G12C | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2021-10-28 | — | — | WO | disclosed |