Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TLR4 | O00206 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL183877 | 1.00 | KMT2A (0.43) | KMT2AMEN1ALDH1A1MAPTKDM4E | |
| SCHEMBL24359191 | 0.88 | ALDH1A1 (0.36) | KMT2AMEN1ALDH1A1MAPTKDM4E | |
| SCHEMBL2476888 | 0.85 | ALDH1A1 (0.35) | KMT2AMEN1ALDH1A1MAPTKDM4E | |
| SCHEMBL31544797 | 0.84 | TLR4 (0.39) | KMT2AMEN1ALDH1A1MAPTKDM4E | |
| SCHEMBL5227279 | 0.82 | NPC1 (0.33) | ALDH1A1MAPTKDM4ERAB9A | |
| SCHEMBL13039618 | 0.75 | NPC1 (0.41) | KMT2AMEN1RAB9ALMNA | |
| SCHEMBL9718446 | 0.75 | ALDH1A1 (0.49) | KMT2AMEN1ALDH1A1MAPTKDM4E | |
| SCHEMBL4773759 | 0.74 | NPC1 (0.37) | RAB9ALMNA | |
| SCHEMBL1134463 | 0.73 | ALDH1A1 (0.53) | KMT2AMEN1ALDH1A1MAPTKDM4E | |
| SCHEMBL24249958 | 0.73 | TLR4 (0.49) | KMT2AMEN1ALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021216770-A1 | SUBSTITUTED TETRAHYDROQUINAZOLINE COMPOUNDS AS KRAS INHIBITORS | ACCUTAR BIOTECHNOLOGY INC. (US) | 2021-10-28 | — | — | WO | disclosed |