Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2393671 | 0.85 | KMT2A (0.58) | LMNAMAPK1L3MBTL1KMT2AMAPT | |
| SCHEMBL2392538 | 0.84 | MAPT (0.62) | LMNAMAPK1L3MBTL1CASP3SENP7 | |
| SCHEMBL2393841 | 0.84 | MAPT (0.51) | LMNAL3MBTL1KMT2AMAPTMEN1 | |
| SCHEMBL2410276 | 0.79 | GAA (0.51) | LMNAKMT2AMEN1HSD17B10SMN1; SMN2 | |
| SCHEMBL2410280 | 0.79 | GAA (0.51) | LMNAKMT2AMEN1HSD17B10SMN1; SMN2 | |
| SCHEMBL6327817 | 0.75 | LMNA (0.73) | LMNAMAPK1L3MBTL1CASP3SENP7 | |
| SCHEMBL11847871 | 0.75 | LMNA (0.64) | LMNAMAPK1L3MBTL1CASP3SENP7 | |
| SCHEMBL14499026 | 0.75 | KMT2A (0.57) | LMNAL3MBTL1KMT2AMAPTMEN1 | |
| SCHEMBL10822092 | 0.75 | NPC1 (0.50) | LMNAMAPK1L3MBTL1CASP3SENP7 | |
| SCHEMBL20491505 | 0.75 | LMNA (0.77) | LMNAMAPK1L3MBTL1CASP3SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012901-B1 | Method of synthesizing enantiopure mexiletine analogues and novel β-thiophenoxy and pyridyl ethers | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-09-06 | — | — | US | disclosed |