Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2393671 | 0.85 | KMT2A (0.58) | MAPTKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL2393595 | 0.84 | LMNA (0.51) | MAPTKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL2395102 | 0.83 | MAPT (0.65) | MAPTKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL23980850 | 0.82 | MAPT (0.52) | MAPTKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL2394584 | 0.79 | GAA (0.48) | MAPTKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL2394591 | 0.79 | GAA (0.48) | MAPTKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL23980789 | 0.78 | KMT2A (0.43) | MAPTKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL9220741 | 0.77 | MAPT (0.55) | MAPTKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6202183 | 0.77 | MAPT (0.50) | MAPTKMT2ANPC1RAB9AMEN1 | |
| SCHEMBL27287038 | 0.76 | MAPT (0.47) | MAPTKMT2ANPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012901-B1 | Method of synthesizing enantiopure mexiletine analogues and novel β-thiophenoxy and pyridyl ethers | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-09-06 | — | — | US | disclosed |