Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | MLNR | O43193 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 5/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | FPR3 | P25089 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL377935 | 0.89 | FAAH (0.42) | FAAHMLNRCYP3A4PARP1FPR3 | |
| SCHEMBL2396378 | 0.88 | MLNR (0.45) | BRD4FAAHMLNRCYP3A4ALDH1A1 | |
| SCHEMBL377747 | 0.82 | MLNR (0.54) | MLNRCYP3A4 | |
| SCHEMBL377853 | 0.82 | MLNR (0.52) | MLNRCYP3A4ALDH1A1NPC1MAPT | |
| SCHEMBL377479 | 0.81 | MLNR (0.49) | MLNRCYP3A4 | |
| SCHEMBL2397561 | 0.79 | MLNR (0.44) | MLNRCYP3A4ALDH1A1NPC1MAPT | |
| SCHEMBL377798 | 0.78 | KDM4E (0.49) | FAAHMLNRCYP3A4ALDH1A1FPR3 | |
| SCHEMBL377769 | 0.78 | CCR1 (0.44) | MLNRCYP3A4MEN1KMT2AFPR3 | |
| SCHEMBL2397555 | 0.77 | MLNR (0.52) | MLNRUSP30CCR1 | |
| SCHEMBL2393780 | 0.77 | FAAH (0.40) | FAAHMLNRCYP3A4ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012981-B2 | Benzylpiperazine derivatives as motilin receptor agonists | GLAXO GROUP LIMITED (GB) | 2011-09-06 | — | — | US | disclosed |