Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | MLNR | O43193 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2396382 | 0.87 | MLNR (0.43) | FAAHMLNRCYP3A4DRD4RORC | |
| SCHEMBL377748 | 0.82 | MLNR (0.49) | FAAHMLNRCYP3A4KDM4EALDH1A1 | |
| SCHEMBL377854 | 0.82 | MLNR (0.47) | FAAHMLNRCYP3A4RORC | |
| SCHEMBL377935 | 0.81 | FAAH (0.42) | FAAHMLNRCYP3A4PARP1DRD4 | |
| SCHEMBL2397562 | 0.78 | MLNR (0.39) | FAAHMLNRCYP3A4RORC | |
| SCHEMBL377770 | 0.77 | CHRM4 (0.42) | FAAHMLNR | |
| SCHEMBL377479 | 0.77 | MLNR (0.49) | MLNRCYP3A4 | |
| SCHEMBL2393775 | 0.77 | BRD4 (0.39) | FAAHMLNRCYP3A4PARP1ALDH1A1 | |
| SCHEMBL377588 | 0.76 | CHRM4 (0.45) | FAAHMLNRDRD4MEN1KMT2A | |
| SCHEMBL2397558 | 0.76 | MLNR (0.46) | FAAHMLNRMEN1KMT2AOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012981-B2 | Benzylpiperazine derivatives as motilin receptor agonists | GLAXO GROUP LIMITED (GB) | 2011-09-06 | — | — | US | disclosed |